mRNA

1. Liver cell cytoplasmic membrane (a) HBV infects liver cell. Cell nucleus (b) Polymerase completes DNA strand. (c) Completed viral genome transported to cell nucleus, messenger RNA and RNA copy of genome transcribed. (d) Reverse transcriptase and other viral proteins are translated; assembly of viral capsid begun. (e) Reverse transcription of RNA genome copy packaged in newly forming capsid; RNA strand degraded. (f) Synthesis of complementary DNA strand begun. (g) Replication of second DNA strand ceases as virion buds from cell membrane. HBV mRNA RNA copy of genome RNA DNA HBV

2. Liver cell cytoplasmic membrane (a) HBV infects liver cell. Cell nucleus HBV

3. Liver cell cytoplasmic membrane (a) HBV infects liver cell. Cell nucleus (b) Polymerase completes DNA strand. HBV

4. Liver cell cytoplasmic membrane (a) HBV infects liver cell. Cell nucleus (b) Polymerase completes DNA strand. (c) Completed viral genome transported to cell nucleus, messenger RNA and RNA copy of genome transcribed. HBV mRNA RNA copy of genome

5. Liver cell cytoplasmic membrane (a) HBV infects liver cell. Cell nucleus (b) Polymerase completes DNA strand. (c) Completed viral genome transported to cell nucleus, messenger RNA and RNA copy of genome transcribed. (d) Reverse transcriptase and other viral proteins are translated; HBV mRNA RNA copy of genome

6. Liver cell cytoplasmic membrane (a) HBV infects liver cell. Cell nucleus (b) Polymerase completes DNA strand. (c) Completed viral genome transported to cell nucleus, messenger RNA and RNA copy of genome transcribed. (d) Reverse transcriptase and other viral proteins are translated; assembly of viral capsid begun. HBV mRNA RNA copy of genome

7. Liver cell cytoplasmic membrane (a) HBV infects liver cell. Cell nucleus (b) Polymerase completes DNA strand. (c) Completed viral genome transported to cell nucleus, messenger RNA and RNA copy of genome transcribed. (d) Reverse transcriptase and other viral proteins are translated; assembly of viral capsid begun. (e) Reverse transcription of RNA genome copy packaged in newly forming capsid; RNA strand degraded. HBV mRNA RNA copy of genome RNA DNA

8. Liver cell cytoplasmic membrane (a) HBV infects liver cell. Cell nucleus (b) Polymerase completes DNA strand. (c) Completed viral genome transported to cell nucleus, messenger RNA and RNA copy of genome transcribed. (d) Reverse transcriptase and other viral proteins are translated; assembly of viral capsid begun. (e) Reverse transcription of RNA genome copy packaged in newly forming capsid; RNA strand degraded. HBV mRNA RNA copy of genome RNA DNA

9. Liver cell cytoplasmic membrane (a) HBV infects liver cell. Cell nucleus (b) Polymerase completes DNA strand. (c) Completed viral genome transported to cell nucleus, messenger RNA and RNA copy of genome transcribed. (d) Reverse transcriptase and other viral proteins are translated; assembly of viral capsid begun. (e) Reverse transcription of RNA genome copy packaged in newly forming capsid; RNA strand degraded. (f) Synthesis of complementary DNA strand begun. HBV mRNA RNA copy of genome RNA DNA

10. Liver cell cytoplasmic membrane (a) HBV infects liver cell. Cell nucleus (b) Polymerase completes DNA strand. (c) Completed viral genome transported to cell nucleus, messenger RNA and RNA copy of genome transcribed. (d) Reverse transcriptase and other viral proteins are translated; assembly of viral capsid begun. (e) Reverse transcription of RNA genome copy packaged in newly forming capsid; RNA strand degraded. (f) Synthesis of complementary DNA strand begun. (g) Replication of second DNA strand ceases as virion buds from cell membrane. HBV mRNA RNA copy of genome RNA DNA HBV