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Figure 1

CaM-Seph. CaM-Seph. + Suramin. + Suramin. Seph. Seph. Input. Figure 1. A. IP 3 R1. B. EGTA. Ca 2+. IP 3 R1 1-225. EGTA. Ca 2+. Figure 2. A. P 49-81. B. P 106-128. a b c d e f g h. a b c d e f g h. EGTA. Ca 2+. 0. 12.5.

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Figure 1

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  1. CaM-Seph CaM-Seph + Suramin + Suramin Seph Seph Input Figure 1 A IP3R1 B EGTA Ca 2+ IP3R1 1-225 EGTA Ca 2+

  2. Figure 2 A P 49-81 B P 106-128 a b c d e f g h a b c d e f g h EGTA Ca2+ 0 12.5 25 37.5 50 75 100 0 12.5 25 37.5 50 75 100 [Suramin] (µM) [Suramin] (µM) C D

  3. Figure 3 1499 1649 100 % 1-5-8-14 76 % IQ 60 % IQ 72% 1-5-8-14 A 1554-ldsqvnnlflkshnivqkta-1573 1554-ldsqvnnlflkshnivqktalnwrlsarnaar-1585 1564-kshnivqktalnwrlsarnaar-1585 1564-kshnivqktalnwrlsarnaarrdsvlaasrd-1595 B C a b c d e a b c d e Ca2+ EGTA D CaM P1554-1573 P1554-1585 P1564-1585 P1564-1595

  4. 0 12.5 25 50 75 100 [Suramin] (µM) Figure 4 A a b c d e f g EGTA Ca2+ B

  5. Figure 5 A Lvec L15 B C

  6. Figure 6

  7. Figure 7 A Lbs1 Lbs1 Δ1-225 * control suramin control suramin B IP3R1 Δ1-225 IP3R1 * control suramin control suramin

  8. Figure 8

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