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Affect of DNA-PK on Foci Persistence

Affect of DNA-PK on Foci Persistence. J. Dickey. J Cell Controls (0 Gy). 0 hr. 48 hr. 24 hr. 72 hr. K Cell Controls (0 Gy). 0 hr. 48 hr. 24 hr. 72 hr. J Cells 3 Gy. 0.5 hr. 1 hr. 3 hr. 6 hr. 10 hr. 24 hr. 48 hr. 72 hr. K Cells 3 Gy. 0.5 hr. 1 hr. 3 hr. 6 hr. 10 hr. 24 hr.

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Affect of DNA-PK on Foci Persistence

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  1. Affect of DNA-PK on Foci Persistence J. Dickey

  2. J Cell Controls (0 Gy) 0 hr 48 hr 24 hr 72 hr

  3. K Cell Controls (0 Gy) 0 hr 48 hr 24 hr 72 hr

  4. J Cells 3 Gy 0.5 hr 1 hr 3 hr 6 hr 10 hr 24 hr 48 hr 72 hr

  5. K Cells 3 Gy 0.5 hr 1 hr 3 hr 6 hr 10 hr 24 hr 48 hr 72 hr

  6. J Cells 5 Gy 0.5 hr 1 hr 3 hr 6 hr 10 hr 24 hr 48 hr 72 hr

  7. K Cells 5 Gy 0.5 hr 1 hr 3 hr 6 hr 10 hr 24 hr 48 hr 72 hr

  8. J vs. K cells 10 hr post 3 Gy IR J Cells K Cells

  9. J vs. K cells 10 hr post 5 Gy IR J Cells K Cells

  10. Conclusions • J cells (deficient in DNA-PK expression) have greater foci persistence over time after IR. • Overall numbers of foci between J cells and K cells at 30 min post-IR seem similar. • DNA-PK seems to play a role in foci removal.

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