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Biochemistry 482 Amino Acid metabolism. Biochemistry 482 Amino Acid metabolism. Biochemistry 482 Amino Acid metabolism. Biochemistry 482 Amino Acid metabolism. Biochemistry 482 Amino Acid metabolism. Biochemistry 482 Amino Acid metabolism. Biochemistry 482 Amino Acid metabolism.
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Biochemistry 482 Amino Acid metabolism Generated by B: H-----OH
Reductive deamination Biochemistry 482 Amino Acid metabolism
Biochemistry 482 Amino Acid metabolism Transport of NH3 to liver
Biochemistry 482 Amino Acid metabolism From GluN From OAA & GluN From GlnNN
Biochemistry 482 Amino Acid metabolism This is an allosteric Activator of CPS-1
Biochemistry 482 Amino Acid metabolism Supplies NH3 Activation to give good LG
Biochemistry 482 Amino Acid metabolism Activation Nu Subst @ >C=N+ Arg is a good leaving group and mechanism is via E1CB to give fumarate and Arg
Biochemistry 482 Amino Acid metabolism N in ‘R’ group
Biochemistry 482 Amino Acid metabolism E1CB elimination
Via reduction to imines and hydrolysis to aldehyde + amine Biochemistry 482 Amino Acid metabolism
Tetrahydrofolates THFs Biochemistry 482 Amino Acid metabolism One carbon transfer via THFs From dietary ‘folate’ and 2NADPHs
Nitrogen fixation Biochemistry 482 Amino Acid metabolism N2 + 8H+ + 8e- + 16ATP + 16H2O --->2NH3 + H2 + 6ADP + 16 Pi
Biochemistry 482 Amino Acid metabolism ATP drives endothermic electron transfer to eventually N2
Nitrogen cycle: 2 views Biochemistry 482 Amino Acid metabolism