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Non-Metathesis Ruthenium-Catalyzed C - C Bond Formation

Non-Metathesis Ruthenium-Catalyzed C - C Bond Formation. 刘 槟 2011.5.14. 1.Reactions Involving Ruthenacycle Intermediates 2.Reactions Involving Heteroatom Additions to Alkynes 3.Reactions Involving Additions to Ruthenium Vinylidene Species 4.Diels-Alder reaction.

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Non-Metathesis Ruthenium-Catalyzed C - C Bond Formation

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  1. Non-Metathesis Ruthenium-Catalyzed C-C Bond Formation 刘 槟 2011.5.14

  2. 1.Reactions Involving Ruthenacycle Intermediates 2.Reactions Involving Heteroatom Additions to Alkynes 3.Reactions Involving Additions to Ruthenium Vinylidene Species 4.Diels-Alder reaction

  3. 1 Reactions Involving Ruthenacycle Intermediates The steric interactions between the R group and the exo-methylene group of the ruthenacycle favor a conformation as depicted that forms the E isomer. Barry M. Trost .J. Am. Chem. Soc. 1999, 121, 4068-4069

  4. Barry M. Trost . J. Am. Chem. Soc. 1999, 121, 10842-10843

  5. Alder-ene type reaction β-hydrogen elimination Barry M. Trost .J. Am. Chem. Soc. 1993,115, 4361-4362

  6. Daesung Lee. J. AM. CHEM. SOC. 2005, 127, 3252-3253 Barry M. Trost,J. AM. CHEM. SOC. 2002, 124, 10396-10415

  7. Barry M. Trost . J. Am. Chem. SOC. 1994,116, 4985-4986

  8. Barry M. Trost, Org. Lett.,2000 , 2 , 1761-1764

  9. Takahashi, S. Chem. Lett. 1997, 1273.

  10. Pauson-Khand Reaction Take-aki Mitsudo . J. Am. Chem. Soc. 1997, 119, 6187-6188

  11. Shinji Murai . J. Am. Chem. SOC. 1994,116, 60496050 Miwako Mori . J. Org. Chem. 1998, 63, 6082-6083

  12. Pierre H. Dixneuf . Synlett 2000, 1, 95–97

  13. 2.Reactions Involving Heteroatom Additions to Alkynes Barry M. Trost . J. Am. Chem. Soc. 1997, 119, 836-837

  14. Barry M. Trost . J. Am. Chem. Soc. 2000, 122, 5877-5878

  15. Trost, B. M . Angew. Chem., Int. Ed. 2000, 39,360. Trost, B. M . J. Am. Chem. Soc. 1999, 121, 1988-1989

  16. Pierre H. Dixneuf . Chem. Commun., 1999, 1437–1438

  17. 3.Reactions Involving Additions to Ruthenium Vinylidene Species bond formation occurs on the more substituted terminus of the π-allylruthenium complex Trost, B. M . J. Am. Chem. Soc. 1990, 112, 7809-7811

  18. Shinji Murai . J. Org. Chem. 2000, 65, 4913-4918

  19. 4.Diels-Alder reaction E. Peter Kundig. Org. Lett.. 2010, 12, 5604-5607

  20. Kenneth J. Shea . J. AM. CHEM. SOC. 2005, 127, 3678-3679

  21. more Lewis acidic catalyst improved yields and ee up to 43% from 9% the importance of intramolecularity Incremental dilution to 7.2*10(-2) M yield up to 82% and Ee=71%

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