1 / 15

Examining The Significance of Extreme Longevity Studies

Dive into the importance of supercentenarian studies for understanding aging theories and mortality kinetics, exploring historical insights and contemporary relevance. Explore the non-Gompertzian mortality kinetics in various species and industries, shedding light on age-ascertainment biases in longevity data.

smillar
Download Presentation

Examining The Significance of Extreme Longevity Studies

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Discussion of the Paper:“IDL, the International Database on Longevity”Living to 100 SymposiumSociety of Actuaries Leonid A. Gavrilov, Ph.D. Center on Aging NORC and University of Chicago Chicago, Illinois, USA

  2. Disclaimer • This discussion may be incomplete because the discussed paper was received only at the Symposium

  3. Why Supercentenarian Studies are so Important? • Extreme cases are particularly informative for discriminating between competing theories (Peter Kapitsa, physicist, Nobel prize winner) • Extreme cases of longevity are particularly informative for discriminating between competing theories of aging and longevity

  4. Historical Note • Early studies starting with Gompertz (1825) himself suggested mortality deceleration and leveling-off at advanced ages • Later studies by British researchers, Greenwood and Irwin (1939) suggested that mortality force becomes constant at extreme old ages

  5. M. Greenwood, J. O. Irwin. BIOSTATISTICS OF SENILITY

  6. Mortality at Advanced Ages Source:Gavrilov L.A., Gavrilova N.S. The Biology of Life Span: A Quantitative Approach, NY: Harwood Academic Publisher, 1991

  7. Constant failure rate at extreme old ages was also predicted by the reliability theory of aging and longevity • Gavrilov L.A., Gavrilova N.S. The Biology of Life Span: A Quantitative Approach, NY: Harwood Academic Publisher, 1991 • Gavrilov, L.A., Gavrilova, N.S. The reliability theory of aging and longevity. J. Theor. Biol. 213, 527-545, 2001.

  8. Non-Gompertzian Mortality Kinetics of Four Invertebrate Species Non-Gompertzian mortality kinetics of four invertebrate species: nematodes, Campanularia flexuosa, rotifers and shrimp. Source: A. Economos. A non-Gompertzian paradigm for mortality kinetics of metazoan animals and failure kinetics of manufactured products. AGE, 1979, 2: 74-76.

  9. Non-Gompertzian Mortality Kinetics of Three Rodent Species Non-Gompertzian mortality kinetics of three rodent species: guinea pigs, rats and mice. Source: A. Economos. A non-Gompertzian paradigm for mortality kinetics of metazoan animals and failure kinetics of manufactured products. AGE, 1979, 2: 74-76.

  10. Non-Gompertzian Mortality Kinetics of Three Industrial Materials Non-Gompertzian mortality kinetics of three industrial materials: steel, industrial relays and motor heat insulators. Source: A. Economos. A non-Gompertzian paradigm for mortality kinetics of metazoan animals and failure kinetics of manufactured products. AGE, 1979, 2: 74-76.

  11. Thus, the conclusion of the discussed paper: “… Striking feature of these [supercentenarian] survival curves is the seemingly exponential decline in survival probabilities” fits well with the earlier studies and theoretical predictions (except that these earlier studies are not cited in the discussed paper)

  12. Remaining questions and methodological concerns • Where is the proof that the list of supercentenarians is indeed complete or age-ascertainment-bias free? • Where are the data themselves? There are no data in the announced www.supercentenarians.org

  13. Specific question for discussion “… this [supercentenarian] list is assumed to be age-ascertaintment-bias free (Kestenbaum and Fergusson, 2002…) Questions for discussion: • Is this list really bias-free? • How do we know that it is unbiased?

More Related