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Biotechnology and Bioindustry in China

Biotechnology and Bioindustry in China. Dr. Yinhong Zhao China National Centre for Biotechnology Development (CNCBD) Ministry of Science and Technology (MOST) China. Main Topics. 1. Policy and Approaches 2. Priorities and Key Technologies 3. Biological resources

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Biotechnology and Bioindustry in China

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  1. Biotechnology and Bioindustry in China Dr. Yinhong Zhao China National Centre for Biotechnology Development (CNCBD) Ministry of Science and Technology (MOST) China

  2. Main Topics • 1. Policy and Approaches • 2. Priorities and Key Technologies • 3. Biological resources • 4. Talents and Organizations • 5. Achievements • 6. Bio-safety • 6. Biotechnology Industry • 8. Administration of BT and BI

  3. BT, BI, BE in the World Biotechnology (BT) is the largest field of R&D in many countries Biotechnology industry (BI) is becoming the growing point of the economy Biotechnology economy (BE) will be the next new economy of the world

  4. Biotechnology Situation in China The Chinese government has made great efforts on research and development of biotechnology and its industrializationBiotechnology research and development area is the largest priority in China.Bioindustry is rising abruptly.

  5. 1. Policy and Approaches • The key approach for biotechnology development is to • encourage innovation and progress of BT • very prudently promote biotechnology • promote sustainability of economy by BE • ensure the bio-safety

  6. 2. Priorities and Key Technologies • The priority research areas • basic biology, biomedicine, bioagriculture, bioenvironmental technology, biodiversity and biosafety etc. • The key technologies • functional genome, proteome, biochips, tissue engineering, bioreactors of animals and plants, gene engineering pharmaceutical and vaccines, gene therapy and the transgenic technology of animals and plants, bio-pesticide, bio-fertilizer, bio-safety and others.

  7. 3. China is one of the countries with the richest biological resources and diversity • Territory length is about 5200 km from east to west,5500 km from north to south • coastline of mainland is over 18000 km • area of land is about 9.6million km2 • A vast territory stretching from the cold zone,the temperate zone to the tropics • The inland sea level altitudes from -155 to 8848 meters

  8. 3. China is one of the countries with the richest biological resources and diversity “Mother of World Garden” • Approximately 0.26 million species of animals, plants and microbes. • Over 30,000 species for plants, 200,000 species for animals, 30,000 species for microorganisms.

  9. 3. China is one of the countries with the richest biological resources and diversity • 3,000 family species of the Chinese people related with major illness collected • 0.32 million units of idioplasmatic resources of crops collected

  10. 4. Talents and Organizations • Nearly 200 major biotechnology laboratories • More than 20,000 technological and research personnel

  11. —Government：about 10 billion in the tenth “five-year plan” MOST：more than 5.7 billion yuan 863: 2.8 billion yuan 973: 1.2 billion yuan（including national key laboratories） talents：900 million yuan Special funding: 800 millionyuan CPC: 1 billion yuan NSFC: 1.5 billion yuan CAS: 500 million yuan Local governments: 1 billion yuan —Enterprises: 500 million yuan (estimated) Expenditure

  12. 5. Achievements in the field of Biotechnology in China • basic research • agriculture • pharmaceuticals • environment and energy • application in industry

  13. 1% human genomic research Sequencing of the whole rice genome (9311) Cloning of disease-related genes to neural deafness Dentinogenesis imperfecta type II (DGI-II) Cloning of cattle, lamb, rabbit, mouse 5-1Achievements in basic research

  14. 5-2 Achievements in agriculture • Two-line hybrid rice • Disease-resistant wheat: powdery mildew, yellow dwarf disease, wheat scab • Insect-resistant rice • Transgenic cow, fish, lamb, pig and rabbit • Biological pesticide: BT insecticide • Biofertilizer: recombinant nitrogen-fixing bacteria • Biological forage additives: phytase

  15. Food Supply and Population Increase Biotechnology Provide Great Potential Hybrid Rice: 15 million ha. (more than 1/2 of rice planting area in China) Yield Increase: 20%

  16. Transgenic crops commercialized: Cotton, insect-resistant, Monsanto Co., USA Morning gloray, Peking Univ. Cotton, insect-resistant, CAAS Cotton, insect-resistant (double-resistant), CAAS 5-2Achievements in agriculture Planting area of Bt-Cotton increases steadily. in tHa

  17. China is the 2nd country which possess a complete set of production techniques of insect-resistant transgenic cotton. Farmers increased their incomes for 60 million US $ by planting BT cotton in the last five years.

  18. Disease-resistant, insect-resistant, herbicide-tolerantrice varieties and rapid-growing carp can be commercialized at right moment.

  19. GMO approvals in China

  20. Mammary gland bioreactor is being developed.

  21. Biofertilizer • A 10,000-ton production line has been set up to produce DNA-recombinant nitrogen-fixing bacteria. • 5 DNA-recombinant microbial preparations like vaccines for domesticable animals and 3 microbial insecticides such as trans-BT gene microbial preparations have already been authorized.

  22. 5-3 Achievements in pharmaceuticals 21 various drugs and vaccines have been commercialized. About150 drugs are in clinical trials. 6 genetic solutions, and 6 tissue engineering products like bone, cartilage, skin, ligament are in clinical trials.

  23. Recombinant Drugs and Vaccines in China IFN-1b IFN-2a IFN-2b IFN- IL-2 GM-CSF G-CSF SK EPO EGF FGF Derivatives bFGF Insulin GH TPO TNF Derivatives Gene Engineering Cell Preparation of Thymide Kinase Hepatitis B Vaccine Dysentery Vaccine

  24. Bioproducts Approved for Clinical Trial in China rhEGF rhEGF derivatives rhEGF derivatives for external use rhGF for injection rb bFGF (fused protein) eye ointment rh bFGF for external use rhEPO Recombinant human histologic plasminogen activator for injection rSK for injection rhIL-2 for injection rhIL-2(125Ser) for injection rhIL-11 rhIL-3 for injection Recombinant hepatitis B vaccine Recombinant adenovirus-P53(SBN-1) for injection against cancer New type rhTNF for injection rhTNF- derivatives for injection Gene engineering cell preparation of Thymidine Kinase Recombinant staphylokinase Lyophilized human fibrin adhesive for external use rhTPO for injection rhIFN-1b Polylycol recombinant human mega-karyocyte growth factor for injection rhIFN-1b vagina effervescent rhIFN-2a rhIFN-2a for injection (excretion expression) rhIFN-2a for injection (yeast) rhIFN-2b rhIFN- for injection rhIFN-2b for injection (yeast)

  25. 5-4 Biotechnology in environment and energy China has started research programs concerning: • the alcohol fuel, • control of water pollution, • garbage disposal, • greenery of barren mountains, desert • others.

  26. Many important industrial chemicals like polypropylene amide, glycerol, DC12, DC13 are produced by means of microbial fermentation in place of the traditional chemosynthesis method. The production capacity of polypropylene amide almost reaches 10,000 ton level. 5-5 Application of biotechnology in industry

  27. 6. The Chinese government highly attaches great importance to bio-safety Regulations followed have been issued: • 1993Safety Administration Regulation Genetic Engineering The State Science and Technology Commission • 1996 The Administrative Policy on the Bio-safety of the Genetic Engineering in Agriculture The Ministry of Agriculture • 2001 Management Regulations on the Transgenic Beings in Agriculture The State Council • 2002Management Policy on the Approval of Bio-safety of the Transgenic Beings in Agriculture, Management Policy on the Bio-safety of Import of the Transgenic Beings in Agriculture, Management Policy on Biological Signs of the Transgenic Beings in Agriculture . The Ministry of Agriculture

  28. Regulations followed will be issued: • Management Policy on the Human Genetic Resources (Temporary) The Ministry of Science and Technology (MOST) The Ministry of Health (MOH) The National Administration of Environmental Protection (NAEP) The National Frames of Bio-safety of China • Other regulations or laws related to biosafety are being drafted out by MOST, NAEP, MOA, MOH etc.

  29. —more than 20 bio parks Shanghai High-Tech Industry Development District Zhangjiang High-Tech Development Park Guangzhou International Bio-Island Zhongguanchun Life Science Park, Beijing Over 10 science parks in other provinces —over 500 bio-enterprises： biomedicine: 300 others: 200 7. Biotechnology industry

  30. Zhongguancun Life Science Park

  31. Shenzhen Life Science Park

  32. Sales of biotechnology products（in billion RMB yuan）

  33. 7.2 Advantagesfor Biotechnology Development in China rich in biological resources plant: 30 thousand species animal: 200 thousand species microorganism: 30 thousand species huge potential market large population, large demands for food, health, drug, energy, environment etc. talented personnel about ¼ scientific papers and patterns are contributed by Chinese scientists in the world

  34. 8. The Administration of Biotechnology and Bioindustry in China Basic research High-tech Industrialization NSF NPC MOST GOVERNMENT NETC MOST SEMI-GOVERNMENT CNCBD

  35. Vision and Mission of China National Center for Biotechnology Development(CNCBD) VISION • To be the biggest in China of world first-class management and coordination centers for biotechnology and bio-industry • To be a research center for biotechnology policy • To be a center for project management, personnel training, and international information exchanges • MISSION • policy study • program making • project management • technology consultant • international cooperation • association and society etc.

  36. Director General of CNCBD Secretariat Policy Division Basic Biology Division Biomedicine Division Resource & Biosafety Division Bioagriculture Division Bioindustry Division International Cooperation Division

  37. Website for the Ministry of Science and Technology http://www.most.gov.cn for CNCBD http://www.cncbd.org.cn

  38. 9. International Cooperation With theglobalization of economy, scientific collaboration has become the main stream of the development. China has made great progress in national economy during the past 20 years and we believe that international cooperation will help us to achieve our further goals.

  39. 9. International Cooperation • established active scientific cooperation and exchange programs with 152 countries • signed the agreements with 96 countries for research collaboration • CNCBD has signed collaborative agreement with European Federation of Biotechnology in project European Focus on Biotechnology in China.

  40. Thank You !

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