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Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries, influenced by genetic and environmental factors. Learn about the classification of AMD, risk factors, antioxidants, retinal physiology, and pathogenesis, including treatment options like Anti-VEGF and PDT.
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Age-related macular degeneration (AMD) • The most common cause of blindness in developped countries
Age-related macular degeneration (AMD) • AMD is multifactorial disease caused by combination of predisponing genes and influences of external environment
Classification of AMD • Dry form of drusen, RPE AMD changes, geographic atrophy of RPE
Classification of AMD Wet form of AMD Choroidal neovascularisation
Classification of AMD • CNV classical occult minimally classic
CNV – classic Fluorescence angiography
CNV – classic Fluorescence angiography
CNV – occult Fluorescence angiography
CNV – occult Fluorescence angiography
CNV – minimally classic Fluorescence angiography
CNV – minimally classic Fluorescence angiography
Risc factors of AMD • Genetic factors • Race influences • Gender and hormonal influences • Ophthalmic risc factors
Risc factors of AMD • Vascular risc factors • Environmental influences • Antioxidants level • Comorbidity
Antioxidants • Lutein and zeexantin(the most importantretinalcarotenoids)
Retinal physiology Outer segments of photoreceptors RPE Bruch‘s membrane Choriocapillaris
Ethiopathogenesis of AMD RPE cells with age(apoptosis, necrosis) melanosoms lipofuscin accumulation apoptosis
Ethiopathogenesis of AMD • solubility of Bruch‘s membrane with aging(thickening, granular and vesicular structures) Holz et al (2003) 3 roky 62 let
Ethiopathogenesis of AMD • Drusen • soft (confluent) • hard (solitary) Holz et al (2003)
Ethiopathogenesis of AMD • CNV (choriodalneovascularization) Vascularfactors(VEGF) Holz et al (2003)
Ethiopathogenesis of AMD Physiological status Aging CNV Holz et al (2003)
Therapyof AMD (summary) • Anti VEGF • PDT (photodynamic therapy)