Pre-Pharmacy Society umdprepharm@gmail studentorg.umd/prepharm

1. Pre-Pharmacy Societyumdprepharm@gmail.comstudentorg.umd.edu/prepharm Get on the ListServ...Join Our Facebook Group…Visit Our Website…CMNS Updates 1ST GENERAL BODY MEETING SEPT. 19, 2011

2. Welcome! Don’t forget to sign-in • Active Membership Requirements • PPS Executive Board • Community Service Opportunities • Drug of the Week: Phytocannabinoids • Pharmaceutical Issue: Direct-To-Consumer Advertising (DTCA) • Kaplan Test Prep presented by • Bridget Brennan Agenda

3. 3 Meetings per semester • 3 Hours of Community Service per semester • Please do not wait until till the end of the semester to fulfill your community service hours • Exceptions will not be made Active Membership Requirements

4. President: Joseph Goble • VP of Student Affairs: Sandy Lim • VP of External Affairs: Krishna Dalsania • Secretary: Melissa Etchison • Treasurer: Edward Neuberger • Public Relations Co-Chair: Ben Moy • Public Relations Co-Chair: Long La • Community Service Co-Chair: SahilSheth • Community Service Co-Chair: Lauren Biagiotti Pre-Pharmacy Executive Board 2011-2012

5. Off-Campus Community Service Events

6. Next Wednesday, September 28th • Packing and sorting donated food • Leave from Stamp at 5:00pm (meet in front of ATM outside) • Bring $10.00 for the Metro • Must wear close-toed shoes • 8 people may sign-up • Email: lauren.biagiotti@yahoo.com Capital Area Food Bank, DC

7. When: Tuesday, September 27th from 4-6 PM • Where: Bio Research Building, Room 1103 • What: University of Maryland pre-health societies will be present to provide in depth information and answer questions about their respective fields with the intension of providing students with an educated decision on what student pre-health organization best suites them. Pre-Health Summit

8. Drug of the Week Phytocannabinoids

9. 85 Chemical compounds found in the cannabis plant • Soluble in non-polar organic solvents • Administered by smoking, vaporizing, oral ingestion, transdermal patch, IV injection, sublingual absorption, or rectal suppository • Metabolized in the liver • Stored in fat General Information

10. Receptors found in mammals, birds, fish, and reptiles • CB1- in the basal ganglia, limbic system, cerebellum, and reproductive systems • Not in medulla oblongata (responsible for respiratory and cardiovascular functions) • Responsible for euphoric and anticonvulsive effects • CB2- in the immune system • Responsible for anti-inflammatory effects Receptors

11. Tetrahydrocannabinol (THC)- CB1/CB2 • analgesic (eases moderate pain) • Neuroprotectant (protects neurons from apoptosis) • Cannabidiol (CBD)- has no affinity for either receptor • Antagonizes cannabinoid agonists (like THC, preventing short-term memory loss) • 5-HT1A agonist- involved in antidepressant, anxiolytic, and neuroprotective effects • Cannabinol (CBN)- CB2, some CB1 Most prevalent

12. Dronabinol (Marinol)- appetite stimulant, anti-emetic (anti-nausea/vomiting) • Nabilone (Cesamet) • Sativex- neuropathic pain/spasticity • Rimonabant (Acomplia)- oral spray used for anti-obesity and smoking cessation • HU-331- potential anti-cancer drug • Inhibits topoisomerase II (manage DNA tangles and supercoils) • Levonantradol (Nantrodolum)- anti-emetic and analgesic • Not currently used medically Synthetic Cannabinoids

13. http://norml.org/index.cfm?Group_ID=7002 • http://en.wikipedia.org/wiki/Cannabinoid • http://www.equalrights4all.org/fcda/cannabinoids.htm Sources

14. Pharmaceutical Issue Direct-To-Consumer Advertising (DTCA)

15. DTCA is the promotion of prescription drugs through newspaper, magazine, television, and internet marketing. • Drug companies also produce a range of other materials, including brochures and videos that are available in doctors offices or designed to be given to patients by medical professionals via patient groups. • The United States is only one of two countries where DTCA is legal, however drug industries are campaigning to have DTCA allowed in Europe and Canada. Direct-to-Consumer Advertising

16. The drug industry claims that DTCA advertising helps to ‘educate’ consumer of potential conditions. • It encourages them to see their doctor for diagnosis and treatment. • While acknowledging that DTCA increases the amount spent on prescription drugs, they argue that in the long run early treatment and diagnosis reduces spending on other medical services, such as hospitalisation. Pros

17. Critics of DTCA argue that the industry's advertising is primarily emotional in style as well as appealing in imagery to tactically understate the adverse side-effects and as such is misleading. • Often claimed health benefits are overstated. • DTCA results in over diagnosis of a condition and the inappropriate use of prescription drugs, even where non-drug treatments are as or more effective. • Thus DTCA unnecessarily drive up the cost of healthcare, without guaranteed improvement of the health of those treated. Cons

18. A Drug Topics survey found that 73% of pharmacists attitudes towards DTCA were negative, with feelings that DTCA efforts were “excessive.” Can DTCA techniques be beneficial to pharmacists? If so, how? • As a pharmacist, how would you tell a patient that a drug they found via DTCA methods is “excessive”? • Another issue pertaining to DTCA is pharmaceutical representatives having a lack of knowledge of the product they are selling. How could this be harmful? Discussion

19. Food and Drug Administration. DTC advertising of prescription drugs: selected patient and physician survey findings empowering patients. www.fda.gov/cder/ddmac/Presentations/FDLI2003_090803_ka/FDLI2003_090803.ppt (accessed 2003 Nov 5). • Peter R Mansfield, Barbara Mintzes, Dee Richards, and Les Toop, "Direct to consumer advertising", Editorial, British Medical Journal, January 2005. • Alan Zarembo, "TV Ads for Drugs Help Boost Prescriptions, Researchers Say", Los Angeles Times, April 27, 2005. Sources

20. Pre-Pharmacy Society Proudly Presents… Kaplan Test Prep

21. THE END! THE END! Pre-Pharmacy Societyumdprepharm@gmail.comstudentorg.umd.edu/prepharm Get on the ListServ...Join Our Facebook Group…Visit Our Website…CMNS Updates THE END! THE END! 1ST GENERAL BODY MEETING SEPT 19, 2011