1 / 12

BIOPSYCHOSOCIAL SYSTEMS AFFECTED BY AD

ALZHEIMER PATHOLOGY AND NEUROPLASTICITY AD ATTACKS NEUROPLASTIC MECHANISMS NEUROPLASTICITY AS THE FOCUS OF THE ALZHEMIER ATTACK ALZHEIMER ATTACK AS A MODEL TO UNDERSTAND NEUROPLASTICITY J. Wesson Ashford, M.D., Ph.D. Stanford / VA Aging Clinical Research Center.

sumana
Download Presentation

BIOPSYCHOSOCIAL SYSTEMS AFFECTED BY AD

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. ALZHEIMER PATHOLOGY AND NEUROPLASTICITYAD ATTACKS NEUROPLASTIC MECHANISMSNEUROPLASTICITY AS THE FOCUS OF THE ALZHEMIER ATTACKALZHEIMER ATTACK AS A MODEL TO UNDERSTAND NEUROPLASTICITYJ. Wesson Ashford, M.D., Ph.D.Stanford / VA Aging Clinical Research Center

  2. BIOPSYCHOSOCIAL SYSTEMS AFFECTED BY AD • SOCIAL SYSTEMS • INSTRUMENTAL ADLs - EARLY • BASIC ADLs - LATE • PSYCHOLOGICAL SYSTEMS • PRIMARY LOSS OF SHORT-TERM MEMORY • LEARNING PROCESSES – CLASSICAL, OPERANT • LATER LOSS OF LEARNED SKILLS • NEURONAL MEMORY SYSTEMS • CORTICAL GLUTAMATERGIC STORAGE • SUBCORTICAL • (acetylcholine, norepinephrine, serotonin) • INTRACELLULAR PLASTIC PROCESSES • (tau phosphorylation, Amyloid pre-protein processing)

  3. COGNITIVE PATHOLOGY REFLECTS FAILURES OF MEMORY STORAGE Shown on the next slide is an “Item Response Theory” analysis of the items of the Mini-Mental State Exam (MMSE). The results show that items which are more involved in memory processing are affected earlier in AD (Ashford et al., 1989, 1995).

  4. Mini-Mental State Exam items

  5. CORTICAL PATHOLOGY AFFECTS LOCATIONS OF HIGH MEMORY STORAGE Shown on the next slide is a correlation analysis between brain perfusion (SPECT) and dementia severity (transformed from the MMSE) (Ashford et al., 2000)

  6. PATHOLOGY IN DENDRITES RELATES TO HIGH VOLUMES OF TRANSPORT TO SUPPORT SYNAPTIC PLASTICITY Shown on the next slides is a view which reflects observations from a double labeling (with PHF-1 and MAP-2) analysis of neurons in the cortex affected by Alzheimer’s disease (Ashford et al., 1998).

  7. APOE AND CHOLESTEROL • CHOLESTEROL METABOLISM IS A CENTRAL PART OF SYNAPTIC PLASTICITY (Koudinov & Koudinov, 2001)

  8. APOE AND EVOLUTION(The original allele was APOE-e4, the e3 allele appeared about 300,000 years ago, and the e2 allele appeared about 200,000 years ago) • DOES APOE- e2 or e3 DO A SAFER JOB OF SUPPORTING THE REMODELLING OF DENDRITES, TO MINIMIZE THE STRESS ON THE NEURON OVER TIME? • DEMENTED ELDERLY CANNOT FOSTER THEIR YOUNG OR COMPETE • APOE AS AN AGENT TO SUPPORT SUCCESSFUL AGING IN GRANDMOTHERS • APOE AS AN AGENT TO SUPPORT THE DOMINANCE OF ELDERLY MALES

More Related