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Lecture 14

Lecture 14. QUESTIONS? Text 37607 Msg : 118916 Question. QUESTIONS? Goto http://pollev.com/ucibio Enter question. Last class. -. -. -. “Signaling” in Glycolysis. Example 1: Pyruvate kinase. Fru 2,6-bis-PO 4 regulates Glycolysis. Fru 2,6-bis-PO 4 regulates Glycolysis.

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Lecture 14

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  1. Lecture 14 QUESTIONS? Text 37607 Msg: 118916 Question QUESTIONS? Gotohttp://pollev.com/ucibio Enter question

  2. Last class - - -

  3. “Signaling” in Glycolysis Example 1: Pyruvate kinase

  4. Fru 2,6-bis-PO4 regulates Glycolysis

  5. Fru 2,6-bis-PO4 regulates Glycolysis

  6. “Signaling” to Glycolysis Example 2: Phosphofructokinase 2 PFK2: Fru 6-PO4  Fru 2,6 bis-PO4 Fructose bisphosphatase 2 = reverse PFK2 = Fructose bisphosphatase 2 (FBPase2)! PFK2 Fru 6-PO4 Fru 2,6 bis-PO4 FBPase 2

  7. “Signaling” to Glycolysis Example 2: Phosphofructokinase 2 Huh? Say what? PFK2 = FBPase2? What determines which activity is active?

  8. “Signaling” to Glycolysis – Second messengers Example 2: Phosphofructokinase 2 Remember Glucagon? (In liver) Glucagon activates “Adenylatecyclase” Adenylate cyclase = cyclic AMP (cAMP) cAMP activates Protein Kinase A cAMP is a “second messenger”

  9. Phosphorylation – again! Example 2: Phosphofructokinase 2 Protein Kinase A (PKA) phosphorylates PFK2 PFK2 FBPase2 PO4 Active FBPase2 = ? Glycolysis

  10. Signaling cascade recap Example 2: Phosphofructokinase 2 LIVER Adenylatecyclase Low Glc ? PKA ? Pancreas ? ? Fru2,6 bis-PO4 ? PFK1 ? GLYCOLYSIS

  11. Example 2: Phosphofructokinase 2

  12. Example 2: Phosphofructokinase 2

  13. Signaling cascades IMPORTANT means of regulation Across cells Within cells (Nucleus  Mitochondria) Concept of “second messengers”

  14. Coordinate regulation List all the effects on glucose metabolism Glucagon Insulin

  15. Role of ATP in cells

  16. Role of ATP in cells

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