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The Krebs Cycle

The Krebs Cycle. Occurs in the matrix of the mitochondrion Aerobic phase (requires oxygen) 2-carbon acetyl CoA joins with a 4-carbon compound to form a 6- carbon compound called Citric acid. Citric acid (6C) is gradually converted back to the 4-carbon compound

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The Krebs Cycle

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  1. The Krebs Cycle • Occurs in the matrix of the mitochondrion • Aerobic phase (requires oxygen) • 2-carbon acetyl CoA joins with a 4-carbon compound to form a 6- carbon compound called Citric acid

  2. Citric acid (6C) is gradually converted back to the 4-carbon compound -ready to start the cycle once more • The carbons removed are released as CO2 -enzymes controlling this process called decarboxylases • The hydrogens, which are removed, join with NAD to form NADH2 -enzymes controlling the release of hydrogen are called dehydrogenases

  3. The Cytochrome System • 6 points along pathway where hydrogen is released and temporarily bound to NAD • Reduced coenzyme NADH2 transfers hydrogen to a chain of hydrogen carriers called cytochrome system • These systems are attached to the cristate of every mitochondrion

  4. Transfer of hydrogen from each NADH2 along system -produces 3 ATP -process called oxidative phosphorylation • Complete oxidation of glucose yields 38 ATP -2 during glycolysis -36 during oxidative phosphorylation

  5. The role of oxygen • Final hydrogen acceptor • Combines to form water • Controlled by enzyme cytochrome oxidase • Presence of oxygen also essential for hydrogen to pass along the cytochrome system

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