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Great new Krebs cycle (Citric Acid cycle) movie…

Great new Krebs cycle (Citric Acid cycle) movie…. http:// www.youtube.com/watch?v =A1DjTM1qnPM. fig 16-13. Krebs cycle features and functions …. fig 16-13. O. CH 3 -C. O -. O. O. CH 3 -C. CH 3 -C. it’s all about acetate…. acetate. acetyl group. acetyl coenzyme A or acetyl-CoA.

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Great new Krebs cycle (Citric Acid cycle) movie…

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  1. Great new Krebs cycle (Citric Acid cycle) movie… http://www.youtube.com/watch?v=A1DjTM1qnPM fig 16-13

  2. Krebs cycle features and functions… fig 16-13

  3. O CH3-C O- O O CH3-C CH3-C it’s all about acetate… acetate acetyl group acetyl coenzyme A or acetyl-CoA S-CoA AcCoA rh

  4. all roads lead to acetyl-CoA… fig16-1

  5. electrons from acetyl groups fig16-1

  6. energy from electrons fig16-1

  7. This is HS-CoA, or CoA-SH, CoA, or coenzyme A fig16-3

  8. This is HS-CoA, or CoA-SH, CoA, or coenzyme A CoA-SH, or HS-CoA, or CoA fig16-3

  9. where the acetyl groups come from pyruvate dehydrogenase: PDH fig16-2

  10. Thiamine pyrophosphate (TPP): an activated carbon fig 14-13

  11. TPP as a carbanion nucleophile in pyruvate metabolism fig 14-13

  12. Lipoic acid cofactor of PDH E2 The “business end” of PDH fig16-4

  13. The PDH complex approx. 4.5 x 106 MW fig16-5

  14. The PDH complex fig16-5

  15. The PDH catalytic cycle oxidation of pyruvate fig16-6 (old)

  16. Several reactions, one basic location fig16-6

  17. Please read and LEARN “The Name Game”

  18. The: Krebs cycle citric acid cycle TCA cycle fig16-7

  19. Citrate synthase and its substrates… fig 16-8

  20. Getting fresh carbons into the act why it’s called the citric acid cycle pg 622

  21. making citrate asymmetric remember this for later… pg 622

  22. an iron-sulfer cluster in aconitase fig16-10

  23. electrons! NADH is the main carrier of Krebs cycle-derived electrons pg 624 (less fancy picture)

  24. more electrons! note CoA-SH has re-entered the picture pg 625

  25. direct production of a high energy phosphate but not ATP… instead it’s GTP pg 626

  26. direct production of a high energy phosphate but not ATP… instead it’s GTP pg 626

  27. electrons to FAD instead of NAD+ pg 628

  28. The business end of FAD or FMN isoalloxazine ring rh

  29. electrons to FAD instead of NAD+ pg 628

  30. a sensible inhibitor of succinate dehydrogenase INHIBITOR pg 628

  31. Hydration of fumarate old pg 612

  32. Hydration of fumarate pg 628

  33. substrate product high specificity exemplified by substrates and products of fumarase not a substrate pg 628

  34. substrate product high specificity exemplified by substrates and products of fumarase not a product pg 628

  35. the final electron removal pg 628

  36. Krebs cycle features and functions… fig 16-13

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