1 / 40

Fluoride ( 氟化物 )

Fluoride ( 氟化物 ). 陳弘森 副教授 高雄醫學大學兒童牙科 07-3121101 轉 7008, 7020 hosech@kmu.edu.tw. 學習目標. 氟化物的來源 氟化物的代謝 氟化物的毒性 氟化物的應用 學習資源： Murray JJ: Appropriate use of fluoride for human health. WHO, Geneva, 1996. Fluoride Fluorine. 氟化物 (Fluoride). Fluoride geochemistry 鹵素族第一個 陰電荷最強的元素

tambre
Download Presentation

Fluoride ( 氟化物 )

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Fluoride(氟化物) 陳弘森 副教授 高雄醫學大學兒童牙科 07-3121101轉7008, 7020 hosech@kmu.edu.tw

  2. 學習目標 • 氟化物的來源 • 氟化物的代謝 • 氟化物的毒性 • 氟化物的應用 • 學習資源： • Murray JJ: Appropriate use of fluoride for human health. WHO, Geneva, 1996

  3. FluorideFluorine

  4. 氟化物(Fluoride) Fluoridegeochemistry • 鹵素族第一個 • 陰電荷最強的元素 • 佔地球元素第17位(0.06%)

  5. Inminerals • Fluospar(fluorite)CaF2/氟石 • Cryolite (greenland spare, icetone) Na3AlF6/冰晶石 • Fluorapatite Ca5(PO4)3F/氟磷灰石

  6. In foods • China tea(中國茶) • Chicken(雞肉) • Fish(魚肉) • Taro(芋)

  7. Metabolism of fluoride By oral ↓ Hydrofluoride acid (HF) (Passive diffusion) ↓ Fluoride in blood (plasma) ↓ Ionic form, No ionic form ↓ Soft tissue Bones, teeth ↓ Sweat , Saliva , Breast milk Digestivejuice, Urine ,stool

  8. Organic fluoride(Inhalation anesthesia) Halothane Methoxyflurane Enflurane ↓ Excreted unchanged in expired air

  9. Toxicology of fluoride • Gastrointestinal • Blood chemistry • Cardiovascular system • Neurological

  10. Gastrointestinal • Nausea, Vomiting • Diarrhea, Cramps • Abdominal pain

  11. Blood chemistry • Acidosis • Hypocalcemia • Hypomagnesemia

  12. Cardiovascular system • Week pulse • Hypotension • Pallor, shock • Cardiac irregularities • Ultimately failure

  13. Neurological • Paresthesia , Paresis • Tetany , Coma • CNS depression

  14. Danger The acute lethal dose is about 50mg/kg. The average 5 years old child (B.W. 20kg) 3mg/kg early symptoms

  15. Treatment • Immediate treatment • Induced vomiting • Protection of stomach • Maintenance of blood calcium

  16. Chronic toxic dose

  17. Dental fluorosis

  18. Skeletal fluorosis

  19. Dental benefits of fluoride • Prophylaxis of dental caries • Treatment of sensitive dentine • Treatment of various bone disease

  20. 氟化物對細菌的作用 • 干擾細菌產酸 (1-2 mg/l) • 抑制細菌代謝 (10 mg/l) • 抑制細菌生長 (100~250 mg/l) • 殺死細菌 (1000 mg/l)

  21. ＨF Ｈ＋ +F- Ｈ＋ +F- Bacterial Cell pH7 Ｈ＋ +F-ＨF Fig. 6. Schematic representation of fluoride entering a bacterial cell in the form of HF at lower pH values, dissociating, and thereby providing H+ and F- ions inside the cell. pH4.5 Ｈ＋ +F-ＨF ＨF

  22. Systemic Topic • Toothpaste • Mouth rinses • Painting solution • Varnishes • Sucking tablets • Chewing gum • Drinking water • Tablet salt • Milk • Tablets • Drops

  23. Name Johnny Jones . Address 128 Peaks Street Age 5 . Buchanan, Virginia . Rx Sodium Fluoride Tablets, 2.2 mg (1.0 mg F) Dispense 120 tablets Sig. One tablet each day: chew and swish for one minute before swallowing or allow to dissolve in mouth. Signed Robert L. Smith, D.D.S.

  24. Determine % F in compound %NaF 1/2.2 % SnF2 x molecular wgt, ratio 1/4.1 % Na2P03F 1/7.6

  25. Example • 2% NaF contains 0.91% F 2% x 1/2.2 = 9952 ppm • 0.9% F x 10 = 9.1 mg F/ml • 5 ml of 2% NaF 5 ml x 9.1 mg F/ml = 45.5 mg F

  26. Magnitude of increase between asymptomatic and lethal dose levels of four well-know substances

  27. 結論 • 由本課程可了解氟化物的抗齲齒作用在 牙科公共衛生上所扮演的角色

  28. Thanks for your listening!

More Related