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Brain development

Brain development. The beginning. The beginning. The beginning. Spinal chord and PNS. Spinal chord and PNS. Migration of cells from spinal chord to periphery. Development of motor neurons. Alignment of sensory and motor neurons (motor & proprioception)

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Brain development

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  1. Brain development

  2. The beginning

  3. The beginning

  4. The beginning

  5. Spinal chord and PNS

  6. Spinal chord and PNS Migration of cells from spinal chord to periphery.

  7. Development of motor neurons Alignment of sensory and motor neurons (motor & proprioception) Proper CPG and reflexes require proper development of local circuits

  8. Anterior segments Hindbrain Signaling cascades govern Cell differentiation & Migration Midbrain Mesencephalon Diencephalon Telencephalon

  9. Eyes

  10. Cortical layers Glial fibers

  11. Olfactory neurons From sub-ventricular zone to olfactory bulb

  12. Setting up the connections Where and when should the axon grow?

  13. Eyes to brain Setting up topography…

  14. Motor neurons to muscles Setting up innervation

  15. Cell death

  16. Nerve growth factor Cells are programed to die unless they get NGF….

  17. Synaptic pruning - PNS Competition among synapses

  18. Synaptic pruning - CNS

  19. Synaptic pruning - CNS Occular dominance in a neonate monkey V1

  20. Synaptic pruning is activity dependent Hebbian learning

  21. Synapses during development

  22. Synaptic plasticity Map space with inter-aural differences

  23. Synaptic plasticity

  24. Synaptic plasticity Axonal projections from the Inferior Coliculus to the visual tectum shift. This shift can only happen in young owls…

  25. Critical periods A developmental period with enhanced plasticity. Imprinting

  26. Critical periods Bird song development

  27. Critical periods

  28. Critical periods Innervation of primary visual cortex

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