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pH, Acids, Bases, and Buffers. Solutions. Solute + Solvent = Solution In nature, water is a major solvent. Concentration – measured in moles Molarity – 1 mol is dissolved in water to equal 1 liter. pH. A measure of the acidity and alkalinity of a solution
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Solutions • Solute + Solvent = Solution • In nature, water is a major solvent. • Concentration – measured in moles • Molarity – 1 mol is dissolved in water to equal 1 liter
pH • A measure of the acidity and alkalinity of a solution • Refers to the dissociation of water molecules. • What does this show?
pH • Constant – Kw = 1.0 x 10-14 (mol/L)2 • i.e. water dissociates at a rate of 1 molecule for every 554 million. • At Kw there is an even split of H+ and OH- • 1.0 x 10-7 each • pH is the negative log of the [H+] in mol/L
pH • Since pH is calculated in log, a change in pH of 1 = a 10x change in the [H+] • pH 1 is 10x smaller than a pH of 2. • pH 1 is 100x smaller than a pH of 3.
Problems • [H+] = 1.0 x 10-9 mol/L. Determine the pH. • [OH-] = 1.0 x 10-9 mol/L. Determine the pH. • Acid precipitation has lowered the pH of a particular lake to 4.0. What is the hydrogen ion concentration of the lake?
Acids and Bases • Acids are molecules that release H+ when dissolved in water. • Ex. Citrus Fruit, HCl • Acids make a solution more acidic. • Bases are molecules that release OH- when dissolved in water. • Lyme, Soap, Ammonia • Make solutions more basic.
Acids and Bases • Neutral pH = 7 • Acidic pH <7 • Basic pH >7 • Most biological fluids are within the range of 6-8 • Blood ~ pH of 7.4 • Exceptions??
Buffers • Substances that minimize changes in the concentrations of H+ and OH- in a solution. • Buffers work by accepting H+ from solution when they are in excess and by donating H+ when they have been depleted. • These buffers are usually composed of a weak acid and its base.
Blood • pH = 7.4 • Humans cannot survive for more than a few minutes if the pH drops to 7 or rises to 7.8 • Buffers in the blood work to maintain the pH at or near 7.4 • Ex. Carbonic Acid
Carbonic Acid • Carbonic acid works with bicarbonate as a buffer. • H2CO3 ↔ HCO3- + H+
Organic Compounds • Compounds that contain carbon • Since carbon has 4 valence electrons, it has great versatility. It is able to make 4 covalent bonds. • The major elements of life are C, H, O, N, S, and P
Organic Compounds • Carbon chains form the skeleton of most organic molecules. • Hydrocarbons – consist of only carbon and hydrogen • 3 Types of Isomers • Structural • Geometric • Enantiomers
Structural Isomers • Compounds with the same chemical formula but different structural formulas. • Differ in the covalent arrangement of atoms
Geometric Isomers • Have the same covalent partnerships, but differ in spatial arrangements
Enantiomers • Molecules that are mirror images of each other. • Enantiomers are important in the pharmaceutical industry. • 2 enantiomers of a drug may not be equally effective. From www.elmhurst.edu/~chm/vchembook/209optical.html
Organic Molecules • 4 Types of Organic molecules • Carbohydrates • Lipids • Nucleic Acids • Proteins
Carbohydrates • Abbr. – CHO • Composed of C, H, and O • End in “-ose” • Ex. Glucose, Sucrose, Fructose, Starch • 1 CHO = Monosaccharide • CnH2nOn • Glucose = C6H12O6
CHO’s • monosaccharide + monosaccharide disaccharide + water • This process is called Dehydration Synthesis • Water is removed from the molecules (dehydration) • The two molecules are put together (synthesis)
Monosaccharides Glucose Galactose Fructose Disaccharides Maltose Lactose Sucrose CHO’s
Examples:Sucrose (table sugar) is composed of glucose and fructose.
Polysaccharides • Multiple CHO’s that are put together by dehydration synthesis. • Four important polysaccharides
Lipids • Include fats, oils, waxes, and steroids • All hydrophobic • Consist of 1 glycerol molecule and 3 fatty acids. • 2 types of fats: Saturated and unsaturated • Saturated fats – no C=C double bonds • Unsaturated fats – have C = C double bonds
1 Glycerol molecule with 3 Fatty Acids Fatty acids are hydrocarbon chains Saturated fats have no double bonds between the carbons that make up the hydrocarbon chain. 1 Glycerol molecule with 3 Fatty Acids Have hydrocarbon chains that do contain at least one carbon-carbon double bond (C=C) Saturated and Unsaturated Fats