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Michael Yassa, MD, FRCPC Radiation Oncologist, Hôpital Maisonneuve-Rosemont

Late consequential effects of hypofractionated radiotherapy in prostate cancer: impact of acute toxicity on toxicity at 4 years and 8 years. Michael Yassa, MD, FRCPC Radiation Oncologist, Hôpital Maisonneuve-Rosemont Assistant Professor, University of Montreal myassa.hmr@ssss.gouv.qc.ca

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Michael Yassa, MD, FRCPC Radiation Oncologist, Hôpital Maisonneuve-Rosemont

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  1. Late consequential effects of hypofractionated radiotherapy in prostate cancer: impact of acute toxicity on toxicity at 4 years and 8 years. Michael Yassa, MD, FRCPC Radiation Oncologist, Hôpital Maisonneuve-Rosemont Assistant Professor, University of Montreal myassa.hmr@ssss.gouv.qc.ca P. Vavassis (I), B. Fortin (I), M.A. Fortin (II), C. Lambert (III), T.V. Nguyen (III), and J.P. Bahary (III) I) Department of Radiation Oncology, Hôpital Maisonneuve-Rosemont II) Department of Radiation Oncology, Cité de la Santé de Laval III) Department of Radiation Oncology, CHUM – Hôpital Notre-Dame

  2. Key Points • OBJECTIVE: Evaluate late consequential effects in patients who underwent hypofractionated radiotherapy • 42 patients with intermediate-risk prostate cancer • RT: 57 Gy in 19 fractions (3 Gy per fraction) • Patients followed prospectively (median follow-up 8.4 yrs) • Toxicity recorded according to the NCI-CTC version 2 • Analysis of toxicity in acute phase, at 4 yrs and 8 yrs

  3. Results • Previously reported acute grade 3 GU and GI toxicity were 5% and 0%, respectively. • Of the patients with acute grade 3 GU toxicity, none had toxicity at 4 years and only one patient had grade 2 GU toxicity at 8 years. • No difference in chronic toxicity in patients with acute grade 0-1 toxicity (23% at 8 years) vs. those with acute grade 2-3 toxicity (20% at 8 years).

  4. Results • At 8 years, 79% of patients were asymptomatic

  5. Conclusion • No significant acute or chronic toxicity with this regimen (57Gy in 19 fractions). • No late consequential side effects with hypofractionation in prostate cancer using 3Gy per fractions.

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