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Genes Can Cause Disease: Sickle Cell Disease

Genes Can Cause Disease: Sickle Cell Disease. http://www.sciencemuseum.org.uk/exhibitions/genes/images/1-3-5-1-4-2-1-3-1-0-0.jpg. The change of a single base-pair causes one change in the amino acid sequence of the hemoglobin molecule.

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Genes Can Cause Disease: Sickle Cell Disease

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  1. Genes Can Cause Disease: Sickle Cell Disease http://www.sciencemuseum.org.uk/exhibitions/genes/images/1-3-5-1-4-2-1-3-1-0-0.jpg

  2. The change of a single base-pair causes one change in the amino acid sequence of the hemoglobin molecule http://www.wasdarwinright.com/images/sickle%20cell%20DNA.gif

  3. Normal vs. Sickle Cell Hemoglobin http://evolution.berkeley.edu/evolibrary/images/evo/hemoglobin.gif

  4. Genes can Increase the Risk of Disease: BRCA Genes and Cancer http://en.wikipedia.org/wiki/Image:BRCA_Genes-location_of_BRCA1_and_BRCA2_on_chromosomes_13_and_17.giffrom http://press2.nci.nih.gov/sciencebehind/cioc/survival/49.1.htm

  5. BRCA genes and increased cancer risk BRCA2 is also associated with increased risk of prostate cancer, male breast cancer, and pancreatic cancer. Source: National Cancer Institute (http://www.cancer.gov)

  6. Malnutrition and Disease http://www.usaid.gov/our_work/global_health/nut/images/malnutrition_chart.gif

  7. In the US, Overnutrition is More Prevalent

  8. http://www.wirednewyork.com/hotels/marriott_marquis/images/marriott_marquis_elevators.jpghttp://www.wirednewyork.com/hotels/marriott_marquis/images/marriott_marquis_elevators.jpg

  9. http://www.gkivdo.com/gkii/wire_3.jpg Elevator cable for passenger elevators has a safety factor of about 11

  10. Biological Safety Factors(ratio of capacity to load) • Human Pancreas (enzyme secretion) • About 10 • Human Kidney (plasma filtration) • About 4 • Human Mammary Gland (milk production) • About 3 • Mammalian Lungs (aerobic capacity) • About 1.25 - 2 From: Jared Diamond “Quantitative Evolutionary Design’ J. Physiol 2002, 542: 337-345

  11. Inflammation http://www.biologymad.com/Immunology/inflammation.jpg

  12. http://www.usc.edu/hsc/dental/PTHL312abc/312a/02/Graphics/figure01.gifhttp://www.usc.edu/hsc/dental/PTHL312abc/312a/02/Graphics/figure01.gif

  13. Cilia on the respiratory epithelium

  14. Scarring http://www.shands.org/health/graphics/images/en/10296.jpg

  15. http://www.angelfire.com/ab7/mystro157/year/arnold3.jpg

  16. How Cells DieNecrosis vs. Apoptosis http://pubs.niaaa.nih.gov/publications/arh25-3/image01.gif

  17. Developing human hand before web apoptosis http://www.i-am-pregnant.com/img/day48-hand.gif

  18. Developing hand after web apoptosis http://www.grg.org/breakingnews2001.htm

  19. Ischemic Stroke http://strokecenter.stanford.edu/guide/images/thrombotic.jpg

  20. Modified from: http://www.chrononhotonthologos.com/inactive/strokedr/hbothera.htm Damage Control Apoptosis of Irreversible Injured Cells

  21. http://www.easterncarolinaent.com/Allergy-Triggers-copy.jpg Common Allergens

  22. http://www.euromeds.co.uk/allergy-treatment-information.htm Allergen binds to IgE, which links to mast cells, triggering release of histamine.

  23. The Development of Cancer http://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancergrowth.gif

  24. http://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.htmlhttp://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.html

  25. http://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.htmlhttp://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.html

  26. http://www.medicinenet.com/images/illustrations/butterfly_rash.jpghttp://www.medicinenet.com/images/illustrations/butterfly_rash.jpg

  27. http://www.naturosante.ch/B.L.-lupus-evolution-1.jpg

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