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Chronic Lymphocytic Leukemia (CLL)

Chronic Lymphocytic Leukemia (CLL). Faculty. Chronic Lymphocytic Leukemia. CLL Pathogenesis. Model of Microenvironment Interactions. Role of Cytokines in CLL Biology. Role of Immune Stimulation in CLL. Risk Factors. Familial Incidence. Clinical Course. Clinical Course. Diagnosis: NCI-WG.

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Chronic Lymphocytic Leukemia (CLL)

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  1. Chronic Lymphocytic Leukemia (CLL)

  2. Faculty

  3. Chronic Lymphocytic Leukemia

  4. CLL Pathogenesis

  5. Model of Microenvironment Interactions

  6. Role of Cytokines in CLL Biology

  7. Role of Immune Stimulation in CLL

  8. Risk Factors

  9. Familial Incidence

  10. Clinical Course

  11. Clinical Course

  12. Diagnosis: NCI-WG

  13. B-CLL vs Other Chronic Lymphoproliferative Disorders Differential Diagnosis

  14. Staging Systems

  15. Traditional Prognostic Factors

  16. Survival By Rai StageUntreated CLL

  17. Prognostic Nomogram Using 2-Microglobulin & Clinical Parameters

  18. Genomic Aberrations in CLLInterphase FISH Results82% Abnormal

  19. CLL Disease ProgressionFISH Stratification

  20. CD38 as a Prognostic Factor

  21. Survival Based on IgVH Gene Mutation Status and CD38 Expression

  22. ZAP-70 as a Prognostic Factor

  23. Gene Expression Profiling in CLL and ZAP-70

  24. Prognostic Value of ZAP-70 in Patients With Stage A Binet CLL: Survival

  25. Time From Diagnosis to Initial Therapy by ZAP-70 and IgVH

  26. Prognostic FactorsSummary

  27. NCI-WG Indications to Treat1996-2007

  28. International Workshop on Chronic Lymphocytic Leukemia (IWCLL) 2008 Revised Indications for Treatment

  29. Defining CR in CLLNCI-WG Criteria1996-2007

  30. International Workshop on Chronic Lymphocytic Leukemia (IWCLL) Revised CR Criteria for General Practice

  31. International Workshop on Chronic Lymphocytic Leukemia (IWCLL)Other Response Definition Revisions

  32. Minimal Residual Disease (MRD)as Potential Therapy Endpoint

  33. Long-Term ComplicationsIncidence

  34. Richter’s Transformation

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