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3-Dimensional Structure of Proteins

Explore the 3-Dimensional Structure of Proteins and the 4 levels of protein structure with a focus on Alpha Helices. Discern how internal hydrogen bonding, right-handedness, and R-group interactions influence the stability of Alpha Helices. Learn about the constraints affecting their structure and the common structural units in proteins, including their characteristics and interactions within the protein framework.

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3-Dimensional Structure of Proteins

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  1. 3-Dimensional Structure of Proteins

  2. 4 levels of protein structure:

  3. Alpha Helix Common structure: ~25% of all amino acid residues! (hair…) Optimal use of internal hydrogen bonding: 1st -4th Alpha-helices are generally right handed

  4. 3 7 4 6 2 1 5

  5. Alpha helices have an intrinsic dipole: Interactions of R groups with dipole: Stabilizes or destabilizes the alpha helix 3 constraints affect stability of alpha helix: 1)interactions between adjacent R groups • steric • electrostatic 2) Occurrence of Pro and Gly 3) interactions between AAs at end of helix and intrinsic dipole

  6. Characteristics of alpha helices: Not limited to coiled-coils!! Common structural units

  7. Proteins can have mostly alpha helix, beta sheet, or both Other secondary structures also exist! (tomorrow…)

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