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Applications of SNPs to forensics

Applications of SNPs to forensics. Thore Egeland Rikshospitalet & Section of Medical Statistics, UiO Collaborators: Bente Mevåg, Inst of Forensic medicine, UiO Angel Carracedo, Santiago de C, Spain Geir Dahl, Geir Storvik, UiO, Petter Mostad, Göteborg. Contents. Forensic genetics

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Applications of SNPs to forensics

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  1. Applications of SNPs to forensics Thore Egeland Rikshospitalet & Section of Medical Statistics, UiO Collaborators: Bente Mevåg, Inst of Forensic medicine, UiO Angel Carracedo, Santiago de C, Spain Geir Dahl, Geir Storvik, UiO, Petter Mostad, Göteborg ...

  2. Contents • Forensic genetics • Criminal cases • Mixture evidence, current practice • SNPs, potential benefits • Future projects?

  3. Forensic genetics. Family cases Freeware:http://www.nr.no/familias Used in forensic laboratories in more than 10 countries

  4. Forensic genetics. Biological evidence Criminal cases involving DNA, Norway

  5. Problems with traditional methods • "The interpretation of these mixtures can be a challenging task for the DNA scientist". Ladd et al (2001) • "Powerful methods based on likelihood ratios havebeen developed by Evett et al.(1) and Weir et al.(2) tointerpret mixtures. However, these models presupposeunambiguous identification of alleles prior to analysis andtake no account of their relative peak areas." Gill et al

  6. Why SNP-s? • Problems of interpretation reduced? • May work better than STRs for degraded biological material. • Eventually, cheaper and better suited on a large scale • Many available, may compensate for less variability.

  7. Three main statistical problems • How many markers are needed to1. exclude innocent, 2. determine genotypes of contributors to a stain, 3. obtain sufficiently strong evidence

  8. Example. Future application • A rape has been commited. The genotype of the rapist is determined and used as input to search a database of previous convicts.

  9. Suggestions for project proposal • Design and analyze (in laboratory) controlled experiments. • Determine, develop and implement if necessary, suitable methods. • Analyze data.Competence in many fields required: Biology, Informatics, Forensics, Statistics, ...

  10. References • Evett and Weir (1998). “Interpreting DNA evidence”. Sinauer, MA, USA. • Weir (1995). DNA statistics in the Simpson matter. nat gen, 11, 366-368 • www.nr.no/familias and references therein • Egeland, Dalen and Mostad. To appear in Int J Legal Medicine, 2003.

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