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Genetic sex

Explore the genetic and hormonal mechanisms shaping human sexual development, from initial sex determination to differentiation of male and female reproductive structures. Learn about the role of key genes like SRY and TDF, and the interplay of hormonal pathways in forming testes and ovaries.

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Genetic sex

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  1. Y X X XX XY Genetic sex

  2. Y X XO XY Genetic sex

  3. SRY no SRY Indifferent gonad TDF no TDF Ovary Testis Gonadal sex

  4. No Y sperm Y sperm XX XY SRY No SRY TDF No TDF testis ovary MullerianDucts Wolffian Ducts

  5. Oviduct, uterus degenerates Vas deferens degenerates Mullerian ducts Wolffian ducts

  6. Y sperm No Y sperm XX XY SRY No SRY TDF No TDF testis ovary MullerianDucts oviduct Wolffian Ducts v. def

  7. Oviduct, uterus Vas deferens Testis Mullerian ducts MIH Wolffian ducts T

  8. Y sperm No Y sperm XX XY SRY No SRY TDF No TDF testis T ovary No T No MIH MIH MullerianDucts oviduct T Wolffian Ducts v. def

  9. Undifferentiated genitals Clitoris Vagina Penis Scrotum

  10. + ovary genitals genitals + testis Normally: testis causes dev male genitals ovary causes dev female genitals

  11. + ovary genitals genitals genitals + testis genitals

  12. Testis Undifferentiated genitals Clitoris Vagina Penis Scrotum

  13. X sperm Y sperm XX XY SRY TDF testis T ovary MIH MullerianDucts oviduct T Wolffian Ducts v. def penis vagina

  14. Y sperm No Y sperm XX XY SRY No SRY TDF No TDF testis T ovary No T No MIH MIH MullerianDucts oviduct T Wolffian Ducts v. def penis vagina

  15. X sperm Y sperm XX XY SRY TDF testis T ovary MIH MullerianDucts oviduct T Wolffian Ducts v. def DHT penis vagina

  16. XY testis T MullerianDucts Wolffian Ducts vagina

  17. Y sperm Androgen Insensitivity Syndrome XY SRY TDF testis T Testicular Feminization MIH MullerianDucts T Wolffian Ducts DHT vagina

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