Calcium Channel

1. Calcium Channel Calcium is the oldest and most widely used signaling substance in the cell and is involved in the regulation of almost all biological functions of the body, such as cardiac and muscle contraction, neuronal transmission, learning and memory, embryogenesis and development, cell proliferation and apoptosis, cell division and differentiation, cell energy metabolism, dephosphorylation modification, and gene cytoplasmic free calcium ion concentration of mammalian cells is generally controlled at 100-200 nmol/L. protein expression phosphorylation and regulation. and The The steep but tightly controlled concentration gradient of calcium ions between the cell membrane and the cytoplasm and organelles is maintained and dynamically regulated according to the needs of the cells. It relies on a variety of ion channels, ion pumps, and transporters to work together. Although different cells have different specific mechanisms, the molecules involved in calcium channel is including cell membranes and organelle membrane ion channels (mediating calcium ions into the cytoplasm), transporters of cell membranes and organelle membranes (including primary active transport and secondary transport), cytoplasmic and organelle calcium buffer protein (combined storage of calcium ions), etc. Any abnormality in the links may cause instability of calcium homeostasis and cause disease. Elucidation of the regulation mechanism of calcium channel reveals one of the basic links of calcium homeostasis and the regulation of life processes.