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Tau-phosphorylation

Tau-phosphorylation from Creative Diagnostics.

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Tau-phosphorylation

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  1. Tau Phosphorylation

  2. Tau protein function • Regulate microtubule polymerization • Promotes microtubule stabilization

  3. Tau protein function • Regulation of axonal diameter and growth • Regulation of vesicle and organelle transport • Modulation of signaling cascades by acting as a protein scaffold • Cellular response to heat shock • Adult neurogenesis and the establishment of neuronal polarity in development Lipids Signaling Molecules Cytoskeletal Elements

  4. Tau protein structure Proline-rich region Repeats Acidic region R1 R3 R4 R2 C N • E10 • E10 • E10 E3 E2 C N 17q21 MAPT locus E2 C N C N E2 E3 C N E2 C N

  5. Phosphorylation sites • 28: exclusively phosphorylated in AD brains • 16: phosphorylated both in AD and in control brains • 31: phosphorylated in physiological conditions • 10: putative phosphorylation Serine Threonine Tyrosine

  6. Tau protein kinases

  7. Tau Hyperphosphorylation & Aggregation Tau oligomerization NFTs NFT formation Tau aggregation Tau cleavage & hyperphosphorylation P P P P P P P PHF

  8. www.creative-diagnostics.com Tau Phosphorylation │ 45-1 Ramsey Road, Shirley, NY 11967, USA info@creative-diagnostics.com

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