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CORRIDA ELECTROFORETICA

CORRIDA ELECTROFORETICA. ACETATO DE CELULOSA. -. +. AFSC. ACETATO DE CELULOSA pH ALCALINO. AS. AC. SS. SF. SC. A. INSOLUBLE. SOLUBLE. SOLUBILIDAD. PROBABILIDADES. NORMAL AA. PORTADOR AS/AC/Aß+. ENFERMO SS/SC/Sß+. PROBABILIDADES. AA X AA. AA = 100%. PROBABILIDADES.

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CORRIDA ELECTROFORETICA

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  1. CORRIDA ELECTROFORETICA ACETATO DE CELULOSA - + AFSC ACETATO DE CELULOSA pH ALCALINO AS AC SS SF SC A

  2. INSOLUBLE SOLUBLE SOLUBILIDAD

  3. PROBABILIDADES NORMAL AA PORTADOR AS/AC/Aß+ ENFERMO SS/SC/Sß+

  4. PROBABILIDADES AA X AA AA = 100%

  5. PROBABILIDADES AA X AS AA = 50% AS = 50%

  6. PROBABILIDADES AA X AC AA = 50% AC = 50%

  7. PROBABILIDADES DOS PORTADORES SILENCIOSOS AS X AS AA = 25% AS = 50% SS = 25%

  8. PROBABILIDADES DOS PORTADORES SILENCIOSOS AS X Aß+ AA = 25% AS = 25% Aß+ = 25% Sß+ = 25%

  9. PROBABILIDADES DOS PORTADORES SILENCIOSOS AS X AC AA = 25% AS = 25% AC = 25% SC = 25%

  10. PROBABILIDADES AA X SS AS = 100%

  11. COMPLICACIONES: • Anemia hemolitica cronica • Vasooclusión de la microvasculatura(necrosis) • Infecciones • Secuestro esplénico agudo

  12. HEMOGLOBINOPATÍAS Complicaciones De HbSS Úlcera vascular Necrosis de cadera

  13. HEMOGLOBINOPATÍAS • Causas de Dolor Agudo. • Crisis vasooclusiva. • Síndrome torácico agudo. • Síndrome mano-pie. • Secuestro esplénico. • Priapismo. • Síndrome del cuadrante superior derecho.

  14. HEMOGLOBINOPATÍAS • Causas de Dolor Crónico. • Artritis. • Artropatía • Nécrosis avascular • Úlceras vasculares • Aplastamiento de cuerpos vertebrales.

  15. HEMOGLOBINOPATÍAS • Manejo de Crisis Dolorosa: • Hidratación (D/A 5%, SS½N). • Analgesia adecuada (opiáceos). • Buscar y controlar la causa. • Evitar soluciones con K+ (por la hemólisis) o empezar con 20 meq/L. • Suplementar O2 sólo cuando se documenta hipoxia.

  16. HEMOGLOBINOPATÍAS Manejo del dolor: • Evaluar y NO subestimar el dolor. • Uso temprano y adecuado de opiáceos. • Preferible uso IV o sc de analgésicos • AINES/antihistamínicos. • Reevaluación frecuente/titular analgesia. • Tratamiento adecuado al dar de alta

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