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Blood

Blood. Components of Blood. Whole blood RBCs WBCs Platelets: cell fragments that aid in clotting Plasma 90% water (allows materials to dissolve) Amino acids, glucose, hormones, vitamins, salts, waste Concentrations allows diffusion in/out of blood stream. Platelets.

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Blood

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  1. Blood

  2. Components of Blood • Whole blood • RBCs • WBCs • Platelets: cell fragments that aid in clotting • Plasma • 90% water (allows materials to dissolve) • Amino acids, glucose, hormones, vitamins, salts, waste • Concentrations allows diffusion in/out of blood stream

  3. Platelets • Job: Help form clots to stop bleeding • Proteins form a web to trap cells & platelets

  4. White Blood Cells • Remove foreign invaders & dead cells • Able to move through body tissue

  5. Red Blood Cells • Produced from stem cells in bone marrow • Lose nucleus as they mature • Transport O2 to cells; remove CO2 • O2 binds to hemoglobin proteins • Dead cells filtered by liver & spleen

  6. Sickle Cell Normal

  7. ABO Blood Groups • Antigens: • Proteins on RBC’s that determine your blood type • Help to identify cells as foreign or natural • Analogy: Antigens are like jersey’s • Antibodies: • Part of your immune system • Float freely in plasma • Job: attack foreign antigens

  8. What would happen if a virus with B antigens entered your blood? Your B antibodies will attack and kill this virus. Group A blood Vein • A antigens on the surface of your RBCs • B antibodies in your plasma • only attack invaders with B antigens B antibody B antibody B antibody B antibody

  9. What would happen if you gave this person type A blood? Their A antibodies would attack the donated blood. This person would die. Group B blood Vein A antibody • B antigens on the surface of your RBCs • A antibodies in your blood plasma • only attack invaders with A antigens A antibody A antibody A antibody

  10. Nothing bad would happen. They have no antibodies to attack this blood. Nothing bad would happen. They have no antibodies to attack this blood. What would happen if you gave this person type B blood? What would happen if you gave this person type A blood? Group AB blood Vein • Both A & B antigens on the surface of RBCs • Neither A or B antibodies in your blood plasma

  11. What would happen if you gave this person type A blood? The A antibodies will attack. This person will die. Group O blood Vein • Neither A or B antigens on the surface of your RBCs • Both A & B antibodies in your plasma • will attack invaders with A or B antigens A antibody A antibody B antibody B antibody

  12. What would happen if you gave this person type B blood? The B antibodies will attack. This person will die. Group O blood Vein • Neither A or B antigens on the surface of your RBCs • Both A & B antibodies in your plasma • will attack invaders with A or B antigens A antibody A antibody B antibody B antibody

  13. The A and B antibodies will attack. This person will die. What would happen if you gave this person type AB blood? Group O blood Vein • Neither A or B antigens on the surface of your RBCs • Both A & B antibodies in your plasma • will attack invaders with A or B antigens A antibody A antibody B antibody B antibody

  14. If you have type A blood, can you receive: Type A blood? Type B blood? Type AB blood? Type O blood? Yes No No Yes B antibodies will attack any blood with B antigens.

  15. If you have type B blood, can you receive: Type B blood? Type A blood? Type AB blood? Type O blood? Yes No No Yes A antibodies will attack any blood with A antigens.

  16. If you have type AB blood, can you receive: Type AB blood? Type A blood? Type B blood? Type O blood? Yes Yes Yes Yes They have neither A nor B antibodies.

  17. If you have type O blood, can you receive: Type O blood? Type A blood? Type B blood? Type AB blood? Yes No No No A antibodies will attack any blood with A antigens. B antibodies will attack any blood with B antigens.

  18. Rh Factors • If Rh+ • Cells contain the Rh antigen (jersey) • Don’t contain Rh antibody • Can receive + or - blood • If Rh- • Cells lack the Rh antigen, but… • Contains Rh antibody • Only receive Rh- blood

  19. Practice problem Blood type B+ Which antigens does this person have? A B Rh Which antibodies does this person have? A B Rh

  20. Practice problem Blood type AB+ Which antigens does this person have? A B Rh Which antibodies does this person have? A B Rh

  21. Practice problem Blood type O+ Which antigens does this person have? A B Rh Which antibodies does this person have? A B Rh

  22. Practice problem Blood type AB- Which antigens does this person have? A B Rh Which antibodies does this person have? A B Rh

  23. Practice problem Blood type O- Which antigens does this person have? A B Rh Which antibodies does this person have? A B Rh

  24. Francis was just in a bad accident and lost a lot of blood. He is blood type B+. Can you help save him?

  25. Blood type B+ Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

  26. Francis has B+ blood type because of the B and Rh antigens. If he is given B+ blood in a transfusion… Key Point: A antibodies only attack A antigens Will his antibodies attack this blood? No. Can he receive B+ blood? Yes. Vein A antibody A antibody A antibody

  27. Francis has B+ blood type because of the B and Rh antigens. If he is given B- blood in a transfusion… Key Point: A antibodies only attack A antigens Will his antibodies attack this blood? No. Can he receive B- blood? Yes. Vein A antibody A antibody A antibody

  28. Francis has B+ blood type because of the B and Rh antigens. If he is given A+ blood in a transfusion… Key Point: A antibodies only attack A antigens Will his antibodies attack this blood? Yes. Can he receive A+ blood? No. Agglutination: clumping of the blood Vein A antibody A antibody A antibody

  29. Francis has B+ blood type because of the B and Rh antigens. If he is given A- blood in a transfusion… Key Point: A antibodies only attack A antigens Will his antibodies attack this blood? Yes. Can he receive A- blood? No. Agglutination: clumping of the blood Vein A antibody A antibody A antibody

  30. Francis has B+ blood type because of the B and Rh antigens. If he is given AB+ blood in a transfusion… Key Point: A antibodies only attack A antigens Will his antibodies attack this blood? Yes. Can he receive AB+ blood? No. Agglutination: clumping of the blood Vein A antibody A antibody A antibody

  31. Francis has B+ blood type because of the B and Rh antigens. If he is given AB- blood in a transfusion… Key Point: A antibodies only attack A antigens Will his antibodies attack this blood? Yes. Can he receive AB- blood? No. Agglutination: clumping of the blood Vein A antibody A antibody A antibody

  32. Francis has B+ blood type because of the B and Rh antigens. If he is given O+ blood in a transfusion… Key Point: A antibodies only attack A antigens Will his antibodies attack this blood? No. Can he receive O+ blood? Yes. Vein A antibody A antibody A antibody

  33. Francis has B+ blood type because of the B and Rh antigens. If he is given O- blood in a transfusion… Key Point: A antibodies only attack A antigens Will his antibodies attack this blood? No. Can he receive O- blood? Yes. Vein A antibody A antibody A antibody

  34. Blood Type Internet Lesson

  35. Sebastian was just involved in an accident at work and lost a lot of blood. He is blood type A-. Can you help save him?

  36. Blood type A- Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

  37. Sebastian has A- blood type because of the A antigen. If he is given A- blood in a transfusion… Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Will his antibodies attack this blood? No. Can he receive A- blood? Yes. Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  38. Sebastian has A- blood type because of the A antigen. If he is given A+ blood in a transfusion… Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Will his antibodies attack this blood? Yes. But only the Rh antibodies will attack. Can he receive A+ blood? No. Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  39. Sebastian has A- blood type because of the A antigen. If he is given B- blood in a transfusion… Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Will his antibodies attack this blood? Yes. But only the B antibodies will attack. Can he receive B- blood? No. Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  40. Sebastian has A- blood type because of the A antigen. If he is given B+ blood in a transfusion… Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Will his antibodies attack this blood? Yes. Can he receive B+ blood? No. Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  41. Sebastian has A- blood type because of the A antigen. If he is given AB- blood in a transfusion… Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Will his antibodies attack this blood? Yes. But only the B antibodies attack. Can he receive AB- blood? No. Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  42. Sebastian has A- blood type because of the A antigen. If he is given AB+ blood in a transfusion… Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Will his antibodies attack this blood? Yes. Can he receive AB+ blood? No. Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  43. Sebastian has A- blood type because of the A antigen. If he is given O+ blood in a transfusion… Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Will his antibodies attack this blood? Yes. But only the Rh antibodies will attack. Can he receive O+ blood? No. Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  44. Sebastian has A- blood type because of the A antigen. If he is given O- blood in a transfusion… Key Point: B antibodies attack B antigens Rh antibodies attack Rh antigens Will his antibodies attack this blood? No. His A antibodies only attack A antigens. Can he receive O- blood? Yes. Vein B antibody Rh antibody Rh antibody B antibody B antibody Rh antibody

  45. Review • What are the components found inside blood? • What are the ingredients of plasma? • What is the purpose/function of RBCs? • Which part of blood stop bleeding when cut? • What do antibodies bind with? • If a person has type AB-, which antigens do they possess? Which antibodies? • If a person has type O+, which antigens do they possess? Which antibodies? • If a person is type A-, list all the blood types this person can receive in a transfusion. • If a person is type O-, list all the blood types this person can receive in a transfusion.

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