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Blood Gas Transport: Respiratory Physiology Lectures

Explore the concentration and partial pressure of O2 molecules in air, their transport in solution, and effects of hemoglobin structure. Learn about gas exchange, O2 dissociation curve, CO2 carriage, and more.

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Blood Gas Transport: Respiratory Physiology Lectures

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  1. Blood gas transport Lectures on respiratory physiology

  2. CONCENTRATION AND PARTIAL PRESSURE O2 MOLECULES IN AIR DRY AIR: 21% IS OXYGEN [O2] = 21 ml/dl FO2 = 0.21 AsPB = 760 mm Hg PO2 = 0.21 x 760 mm Hg = 160 mm Hg

  3. EFFECT OF WATER VAPOR 37oC PB = 760 mm Hg PH2O = 47 mm Hg PDRY = 713 mm Hg PO2 = 0.21 x 713 mm Hg = 150 mm Hg

  4. O2 IN PHYSICAL SOLUTION 37oC WATER AFTER EQUILIBRATION, AIR: PO2 = 150 mm Hg AIR WATER: PO2 = 150 mm Hg AIR: [O2] = 21 ml/dl WATER: [O2] = 0.45 ml/dl 37oC SOLUBILITY = 0.45 / 150 = 0.003 ml/(dl.mmHg)

  5. TRANSPORT OF O2 IN SOLUTION DURING EXERCISE Solubility = 0.003 ml/(dl.mmHg) PO2 in arterial blood = 100 mm Hg [O2] = 0.3 ml/dl = 3 ml/liter Cardiac output = 30 liters/min Maximum O2 available = 90 ml/min But O2 requirement is 3000 ml/min

  6. Structure of hemoglobin

  7. Normal cells Sickle cells

  8. Oxygen dissociation curve

  9. ARTERIAL BLOOD VENOUS BLOOD P50 27

  10. TOTAL O2 IN BLOOD IS THE SUM OF Hb-BOUND AND DISSOLVED O2 TOTAL [O2] = 1.39 x [Hb] x % SATURATION/100 + 0.003 x PO2

  11. TOTAL O2 IN ARTERIAL BLOOD (1.39 x 15 x 0.97) + (0.003 x 100) = 20.5 ml/dl

  12. Effects of changing hemoglobin concentration

  13. Shifting the O2 dissociation curve

  14. CO-Hb DISSOCIATION CURVE CO SATURATION, % O2 PARTIAL PRESSURE, mm Hg

  15. Effects of CO on the O2 dissociation curve

  16. Carbon dioxide is carried in the • blood in three forms • Dissolved • As bicarbonate • 3. As carbamino compounds

  17. Solubility of Oxygen 0.003 ml/(dl.mmHg) Solubility of Carbon Dioxide 0.067 ml/(dl.mmHg)

  18. Carriage of CO2 in the blood

  19. Formation of bicarbonate C.A. CO2 + H2O H2CO3 H2CO3 H+ + HCO3-

  20. Formation of carbamino compounds Hb.NH2 + CO2 Hb.NH.COOH

  21. Uptake of CO2 in systemic capillaries

  22. Carriage of CO2 in the blood

  23. CO2 dissociation curves

  24. Comparison of O2 and CO2 dissociation curves

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