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In Taiwan

In Taiwan. Luke Huang & Jessica Leung. Dengue is a tropical febrile disease. … and become a MAJOR pandemic in the last 50 years. Endemic in more than 100 countries 2.5 billion people at risk. www.tatterhood.com/category/gameart/tastyplanet. Dengue fever in Taiwan. How is it spread?.

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In Taiwan

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  1. In Taiwan Luke Huang & Jessica Leung

  2. Dengue is a tropical febrile disease

  3. …and become a MAJOR pandemic in the last 50 years Endemic in more than 100 countries 2.5 billion people at risk www.tatterhood.com/category/gameart/tastyplanet

  4. Dengue fever in Taiwan

  5. How is it spread? Aedes aegypti Aedes albopictus

  6. How it get into our body?

  7. .

  8. 4 Dengue clinical syndromes • Undifferentiated fever; • Classic dengue fever; • Dengue hemorrhagic fever (DHF) • Dengue shock syndrome(DSS) • Dengue shock syndrome is actually a severe form of DHF.

  9. Four Stages of DHF • Stage 1 • Fever and nonspecific constitutional symptoms • Positive tourniquet test is only hemorrhagic manifestation • Stage 2 • Stage 1 manifestations + spontaneous bleeding • Stage 3 • Signs of circulatory failure • (rapid/weak pulse, narrow pulse pressure, hypotension, cold/clammy skin) • Stage 4 • Profound shock (undetectable pulse and BP)

  10. Danger Signs in Dengue Hemorrhagic Fever

  11. 2002 Spread in Taiwan 2005

  12. How did it become a major public health problem? • Ineffective mosquito control • Rapid population growth • Non-biodegradable packaging • Rapid increase in air travel http://farm1.static.flickr.com/81/285601911_f859e04e39.jpg

  13. The Dengue Virus • 4 viral serotypes • Family Flaviviridae • Same family as Yellow Fever

  14. Dengue is an RNA Virus Single strand positive RNA Genome • Capsid (core) • 2. Membrane • 3. Envelope 50 nm

  15. Secondary infections tend to produce DHF…. Antibodies enhance viral replication!

  16. There is no specific treatment for DHF! Can only treat the symptoms

  17. How can we stop it? Mosquito control: Improved water storage Insecticides Introduction of mosquito-eating fish and copepods

  18. Even Better: A Vaccine • Tetravalent live attenuated • Intertypic chimaeric vaccine • Chimaeric vaccine • Effective vaccine still in progress

  19. Reference • "Dengue." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 16 Mar. 2010. Web. 30 Mar. 2010. <http://www.cdc.gov/Dengue/>. • http://www.libertytimes.com.tw/2012/new/jul/26/today-int11.htm • Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention, and Control. 2nd ed. Geneva: World Health Organization, 1997. Print. • "Dengue." World Health Organization. World Health Organization. Web. 30 Mar. 2010. <http://www.who.int/topics/dengue/en/>. • Gubler, D. J., and GoroKuno, eds. Dengue and Dengue Hemorrhagic Fever. Wallingford, Oxon, UK: CAB International, 1997. Print. • Liu, J-W. ,Khor, B-S., Lee, C-H. et al. Dengue Haemorrhagic Fever in Taiwan. 2003. Dengue Bulletin

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