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Prevalence of metabolic abnormalities in HBV-related HCC: clinical study

Prevalence of metabolic abnormalities in HBV-related HCC: clinical study. Jin-Yan Zhao Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Introduction.

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Prevalence of metabolic abnormalities in HBV-related HCC: clinical study

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  1. Prevalence of metabolic abnormalities in HBV-related HCC: clinical study Jin-Yan Zhao Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China

  2. Introduction Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third cause of cancer-related death worldwide. Hepatitis B virus (HBV) infection and hepatitis C virus (HCV) infection played the most role in western and Asia-Pacific region.

  3. Introduction • The relationship between metabolic factors and chronic liver disease including liver cirrhosis (LC) and HCC has become a hot topic. • Metabolic syndrome (MS) has been recognized as a major public health problem worldwide, aroused more and more attention.

  4. Adiponectin↓ Leptin↑ Hypertension ANS↑ HCV infection Obesity RAS↑ Mitochondrial dysfunction ROS↑ Hepatic steatosis Activation of macrophages IR HCC LC Steatohepatitis TNF-α↑ IFN resistance Liver diseases and metabolic syndrome. J Gastroenterology 2008; 43:509–518

  5. Object Previous studies suggested the role of metabolic factors is a newly identified risk factor in HBV-related HCC. The association between metabolic factors and HCC has not been clarified up to now. This case-control study was conducted to investigate the prevalence of metabolic abnormalities in HCC and to probe the association between metabolic parameters and liver function so as to evaluate the role of metabolic abnormalities in the pathogenesis of HBV-related HCC.

  6. Materials and methods Totally 179 cases of HBV-related HCC, who were surgically treated and pathologically confirmed were enrolled in this study. The 150 cases of healthy controls were recruited from routine physical examination. All the metabolic-related parameters and liver function tests were determined with routine biochemical or immunological analytic methods.

  7. Body mass index (BMI) was obtained from medical documentation. MDA and TAOC were adapted by chemical analytic methods. A stratified analysis was conducted according to BMI, GA, FFA and the relationship between the metabolic-related parameters and liver functions were analyzed in both HCC and control subjects.

  8. Statistical analysis The statistical analysis was conducted using SPSS version 11.5 statistical software. Comparisons on HCC and controls using Mann-Whitney U test. Categorical variables were compared using Wilcoxon rank sum test and t test. For Analysis of the correlation between two indicators (liver functions and metabolic parameters): using spearman correlation analysis.

  9. ResultsTable1 Baseline characteristic of HCC and normal subjects There are statistically significant differences in TBIL, TP, ALB, ALT, AFP between the two groups (p<0.05).

  10. Table2 Metabolic parameters in HCC and normal control HCC group showed significantly higher levels of GA and MDA (p < 0.01) than controls, While HCC group showed significantly lower levels of TC, TG, LDL and TAOC (p < 0.01).

  11. Table 3 Changes of metabolic parameters and liver functions in HCC subjects with different BMI The higher BMI, the higher levels of HOMA-IR（homeostasis model assessment for insulin resistance), Insulin, FFA, TG, LDL (P<0.01) and lower level of QUICKI (Quantitative insulin sensitivity check index ) (p<0.05).

  12. Table 4 Changes of metabolic parameters and liver functions in HCC subjects with different GA GLU were significantly higher than normal group ALB was lower than control in HCC. (p<0.05).

  13. Table 5 Changes of metabolic parameters and liver functions in HCC subjects with different FFA According to different levels of FFA, MDA and GGT were significantly higher in abnormal groups than control (p<0.05)

  14. Table 6 Associated study among liver function,tumor marker and metabolic parameters in HCC The parameters reflecting liver functions have obvious correlation with metabolic indicators.

  15. Table 7 Associated study between metabolic parameters in HCC BMI is positive associated with IR, GLU, TG, LDL and negative with HDL. MDA is respectively associated with FFA and HDL. TAOC is correlated with TC, TG, HDL (p<0.05)

  16. Conclusion Metabolic abnormalities were associated with occurre- nce of HBV-related HCC. HCC patients with overweight have insulin resistance, reduced insulin sensitivity and higher plasma insulin level. Elevated MDA and reduced TAOC may lead to liver injury.

  17. Acknowledgement Co-authors Yun-Peng Zhao Xing Gu Jun Ji Chun-Fang Gao* Supported foundation NSFC No.30971345 , Shanghai Science and Technology program 09XD1405800 40.

  18. Thank you For your attention!

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