Nick Lynch AstraZeneca and President, The Pistoia Alliance

1. Nick Lynch AstraZeneca and President, The Pistoia Alliance PRISME Forum Meeting Wellcome Trust Conference Centre, Hinxton, UK 5th May 2011 The Pistoia AllianceStrategy, Progress, Momentum

2. Why Pistoia Alliance? • Industry was at a cross roads • Change in business models were required • We are all in this together (Life Science, vendors, service IT, academics etc) • Need industry applicable services and standards • Bring all the parties together to drive the change • Focus on delivery of projects and prototypes to stimulate and foster new business models

3. The Mission of the Pistoia Alliance Lowering the barriers to innovation by improving the interoperability of R&D business processes via pre-competitive collaborations

4. Signpost clearly

5. Pistoia Membership February2011

7. Boston Conference 2011 • Inaugural meeting April 2011 in Boston • 95 attendees and waitlist of 45 • Over 45 different orgs represented • Good feedback from attendees and will repeat in 2012 • Also plan further topic based meetings later this year – Next Gen Seq etc

8. Domains of Action

9. The Focus of Each Domain 2010-2013 2012-2014 Biology Chemistry 2012+ Scientific Collaboration

10. Some initiatives in the Biology Domain • Sequence Services • SESL

11. Sequence Services – the Rationale “It takes all the running you can do, to keep in the same place!” -- Red Queen

12. Sequence Services Phase 1 (2010) Sequence Services in the Cloud

13. Sequence Services: Deliverables 4 proof-of-concept implementations were built Cognizant & Eagle Constellation & Microsoft Infosys Thomson Reuters Sequence Services site

14. Sequence Services Phase 2 (2011) Management and Analysis of Next Generation Sequencing Data “Bring analysis to the data” e.g. 1,000 Genomes

15. The Biology Domain • Sequence Services • SESL

16. SESL: Try this at your desk…. Which diseases are correlated to TCF7L2? Gene/Protein Literature – Full Text Literature - Abstracts Gene expression Inherited diseases

17. Try it again with Pistoia’s SESL…. • Gene naming/synonyms • Gene Function • Literature statistics • Disease co-occurrences • Gene/protein interactions • …all in one report from one search • HOW? A standard ontology, data model, query language, report structure, etc.

18. Signposting: Standards used in SESL Blending existing standards

19. The Deliverables of SESL • A proof-of-concept to demonstrate feasibility and clarify requirements • A functional specification for query brokering, result filtering, report generation • A potential for a new business model SESL website

20. Pistoia Strategy

21. Life Sciences Information Ecosystem • The scenario: • All industry data services are delivered in an interoperable form so that I can • Buy target data from commercial providers mined from literature • Connect to public services from EBI and NCBI • Use open source, commercial, and proprietary analysis tools in a trusted hosted environment.

22. Life Sciences Information Ecosystem • The scenario: • All industry data services are delivered in an interoperable form so that I can • Buy target data from commercial providers mined from literature • Connect to public services from EBI and NCBI • Use open source, commercial, and proprietary analysis tools in a trusted hosted environment. • The cast: Life Science Scientist Service Provider Commercial Content Provider Software Vendor Public Content Provider Life Science IT

23. Life Sciences Information Ecosystem Increases utilization of a public good and provides commercial advocacy for government investment Hosted solutions are fit for purpose and easy to use. I can find everything I need. Decreases costs and increases the value of the software by reducing number of interfaces that need to be supported. Pistoia compliant services lower cost and decrease time to deliver customer solutions. Increases value of products as data is more easily consumed. Eliminates middleman who reformats, sells data repacked as more consumable. Pistoia compliant services lower cost and decrease time to deliver customer solutions. Life Science Scientist Service Provider Commercial Content Provider Software Vendor Public Content Provider Life Science IT

24. Energy Influence Delivery Trust

25. Our industry needs a Disruptive Innovation. That Disruption...is Pistoia IF YOU WANT TO GO FAST, GO ALONE IF YOU WANT TO GO FAR, GO TOGETHER

26. Discussion and Next steps

27. Life Science Industry – Driving Business Change Ideas & Strategy PRISME New Business Models IMI Standards Lots of Groups out there Driving Business Change Innovation creates quicker cycles of change Pistoia W3C HCLS CDISC Potential collaborations BioIT NIH BBSRC SILA Funding

28. Discussion Its all about delivery! And funding And bringing the right parties together who can deliver

29. How best to work together • We have overlap in organisations and people • Share our strategies • Look for ideas that could become delivery projects • Who do we need to influence for funding and expertise contributions