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Chemical shift. Inductive effects in alkanes Anisotropy Inductive effects in alkenes δ values for different groups 13C chemical shift in different groups Solvents Rotation. Inductive effects in alkanes. Inductive effect and chemical shift. δ-values: Hybridization effects.
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Chemical shift • Inductive effects in alkanes • Anisotropy • Inductive effects in alkenes • δ values for different groups • 13C chemical shift in different groups • Solvents • Rotation
δ-values: Hybridization effects δ values: sp3 < sp2 < sp Carbons with sp2 hybridization hold the electrons closer to the nucelus than do sp3 carbons. This leads to less shielding of the attached protons. Thus vinyl hydrogens have higher chemical shifts than alifatic hydrogens Acetylenic protons (sp-hybridized C) would be expected to have a higher chemical shift than vinyl protons. This is not true due to magnetic anistropy
Magnetic anisotropy A magnetic field with non-uniform density or non-sperical distribution The presence of π-electrons in a magnetic field sets up a small, local current and an anisotropic magnetic field in its close proximity Applies only to atoms with sp2 and sp hybridization
N-H and O-H chemical shift δ: very dependent on solvent and concentration R-O-H: 0,5 < δ < 4,5 R-N-H: 1,0 < δ < 5,0 Carboxylic acids (usually dimeric): 10 < δ 12 Enols: 12 < 18 In deuterated protic solvents: N-H, O-H and S-H can rapidly exchange D with solvent and the 1H-NMR signal disappears.
Solvents Non polar solvents: Small effect on chemical shift Polart + benzene : significant effect on chemical shift