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Óragének (és a melatonin)

Óragének (és a melatonin). Rékási Zoltán PTE ÁOK Anatómiai Intézet. birds. mammals. Melatonin elválasztás explantált patkány tobozmirigyből normál in vitro megvilágítási ciklusban. Melatonin elválasztás explantált csirke tobozmirigyből

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Óragének (és a melatonin)

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  1. Óragének (és a melatonin) Rékási Zoltán PTE ÁOK Anatómiai Intézet

  2. birds mammals

  3. Melatonin elválasztás explantált patkány tobozmirigyből normálin vitromegvilágítási ciklusban

  4. Melatonin elválasztás explantált csirke tobozmirigyből normálin vitromegvilágítási ciklusban

  5. HO HO CH CH CH CH CH CH NH 2 2 2 2 2 2 2 N N N H H H CH NH C 3 O CH 3 NORADRENERGIC and PEPTIDERGIC PATHWAYS LIGHT Adrenergic and VPAC-RECEPTORS SIGNAL TRANSDUCTION SEROTONIN N-acetyltransferase (AA-NAT) AcCoA N-ACETYLSEROTONIN hydroxyindol-o-methyltransferase (HIOMT) SAdM O CH NH C MELATONIN SYNTHESIS 3 O MELATONIN MELATONIN RELEASE

  6. HO HO CH CH CH CH CH CH NH 2 2 2 2 2 2 2 N N N H H H CH NH C 3 O CH 3 LIGHT PHOTORECEPTORS ? ? SIGNAL TRANSDUCTION Clock-genes CLOCK (PACEMAKER) SEROTONIN ? N-acetyltransferase (AA-NAT) AcCoA N-ACETYLSEROTONIN hydroxyindol-o-methyltransferase (HIOMT) SAdM O CH NH C MELATONIN SYNTHESIS 3 O MELATONIN MELATONIN RELEASE

  7. CLOCK BMAL1 Clock Bmal1 Inhibition Activation TIM PER period timeless Four-gene core transcription-translation loop DELAY gene expression time

  8. Clock-genesin Drosophila and mammals PERIOD1 PERIOD2 PERIOD PERIOD3 bHLH/PAS NLS NLS NLS NLS TIMELESS CLOCK CYCLE BMAL1 Doubletime casein kinase I epsilon Cryptochrome1 Cryptochrome Cryptochrome2

  9. Expression pattern of cAANAT, cBmal1 and cClock mRNA in chicken pineal gland

  10. Expression pattern of cAANAT, cBmal1 and cClock mRNA in chicken retina

  11. Expression of retinal and pineal cAANAT mRNA in chicken housed in constant darkness for 1 day or 1 week retina pineal

  12. Expression of retinal and pineal cBmal1 mRNA in chicken housed in constant darkness for 1 day or 1 week retina pineal

  13. Expression of retinal and pineal cAANAT mRNA in chicken housed in constant light for 1 day or 1 week pineal retina

  14. Expression of retinal and pineal cBmal1 mRNA in chicken housed in constant light for 1 day or 1 week retina pineal

  15. Resetting the clock by light Model of circadian clock-work within an individual retinal or pineal photoreceptor cell Clock Bmal1 cCry2 cCry1 cPer2 cPer3 cAANAT Output/melatonin

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