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Dairy and Ovarian Cancer Publication. Genkinger, JM, et al . Dairy Products and Ovarian Cancer: A Pooled Analysis of 12 Cohort Studies. Cancer Epidemiol Biomarkers Prev 2006;15(2):1-9. Cohort studies in the pooled analysis of dairy products and ovarian cancer.
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Dairy and Ovarian Cancer Publication Genkinger, JM, et al. Dairy Products and Ovarian Cancer: A Pooled Analysis of 12 Cohort Studies. Cancer Epidemiol Biomarkers Prev 2006;15(2):1-9.
Cohort studies in the pooled analysis of dairy products and ovarian cancer Canadian National Breast Screening Study (CNBSS) Swedish Mammography Cohort (SMC) Netherlands Cohort Study (NLCS) Nurses’ Health Study (NHSa, NHSb), Nurses’ Health Study II (NHS II), Women’s Health Study (WHS) New York University Women’s Health Study (NYU) New York State Cohort (NYSC) Total cohort size= 553,217 Total # of cases = 2,132 Adventist Health Study (AHS) Breast Cancer Detection Demonstration Project Follow-up Study (BCDDP) Cancer Prevention Study II Nutrition Cohort (CPS II) Iowa Women’s Health Study (IWHS)
Cohort studies in the pooled analysis of dairy products and ovarian cancer
Mean (SD) of Dairy Nutrient and Food Intake aTotal calcium and vitamin D intake includes dietary and supplemental sources.
Pooled Relative Risks for Ovarian Cancer According to Intake of Dairy Foods
Pooled Relative Risks for Ovarian Cancer According to Intake of Dairy Nutrients 1Significant P trend for dietary vitamin D p=0.008
Multivariate Adjusted Pooled Relative Risks for Ovarian Cancer According to Lactose Intake Multivariate RR 10-19.9 793 1.09 (0.97-1.22) <10 785 1.00 (ref) 20-29.9 344 1.07 (0.91-1.25) Range Cases MV RR • 30 210 1.19 (1.01-1.40) Lactose Intake (g/day) 1 serving of milk contains approximately 10g of lactose
New York State Cohort Canadian National Breast Screening Study New York University Women's Health Study Adventist Health Study Nurses' Health Study II Netherlands Cohort Study Women's Health Study Nurses' Health Study (part a) Breast Cancer Detection Demonstration Project Iowa Women's Health Study Swedish Mammography Cohort Nurses' Health Study (part b) Cancer Prevention Study II Combined .2 .5 1 2 5 RelativeRisk Study-specific Pooled Multivariate RRs of Ovarian Cancer and Lactose Intake (>30g/day compared to <10g/day) 1 serving of milk contains approximately 10g of lactose
Pooled relative risks for ovarian cancer according to dairy foods and nutrients, continuous model
Multivariate Adjusted Pooled RR for Histological Subtypes of Ovarian Cancer According to Dairy Food and Nutrient Intake 1P Heterogeneity between studies for dietary calcium=0.02 P Heterogeneity between studies for lactose=0.03