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Nodular Lymphocyte-Predominant Hodgkin’s Disease

Nodular Lymphocyte-Predominant Hodgkin’s Disease. A distinct entity. Characteristics. Clonal proliferation of B cells Distinctive immunophenotype Tumor cells Express: J chain, CD45 and ema Do not express: CD30 and CD15 Normal markers in Sternberg-Reed cells Chronic, relapsing course

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Nodular Lymphocyte-Predominant Hodgkin’s Disease

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  1. Nodular Lymphocyte-Predominant Hodgkin’s Disease

  2. A distinct entity

  3. Characteristics • Clonal proliferation of B cells • Distinctive immunophenotype • Tumor cells • Express: J chain, CD45 and ema • Do not express: CD30 and CD15 • Normal markers in Sternberg-Reed cells • Chronic, relapsing course • Sometimes  diffuse large B cell lymphoma Source: p. 699

  4. Treatment • Controversial • >80% long term survival (regardless of therapy) • CURRENT strategies • No treatment + close follow-up • Radiotherapy – for localized disease • Regimen for Classical HD – for disseminated disease Source: p. 699-700

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