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A. Germinal center B-cells (WT EZH2). B. KARPAS-422 (Y641N EZH2). Gene. Gene. Gene. Gene. -5kb. -5kb. -5kb. -5kb. +5kb. +5kb. +5kb. +5kb. C. Pfeiffer (A677G EZH2). D. WSU-DLCL2 (Y641F EZH2).
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A. Germinal center B-cells (WT EZH2) B. KARPAS-422 (Y641N EZH2) Gene Gene Gene Gene -5kb -5kb -5kb -5kb +5kb +5kb +5kb +5kb C. Pfeiffer (A677G EZH2) D. WSU-DLCL2 (Y641F EZH2) Supp Figure 5. H3K27me3 enrichment in various cell types across genes exhibiting up-regulation, down-regulation, or no change in SUP-B8 cells treated for 72 hours with 500 nM GSK126.