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COX-IV

A. B. C. TFAM. SERCA2a. TFB2M. CSQ. Histone-H3. COX-IV. 1. 1. *. *. 0.75. 0.75. *. SERCA2a relative amount. TFAM relative amount. 0.5. 0.5. 0.25. 0.25. 0. 0. 1. Vehicle. 0.75. *. *. TFB2M relative amount. H 2 O 2 40 m mol/L. 0.5. H 2 O 2 40 m mol/L

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COX-IV

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  1. A B C TFAM SERCA2a TFB2M CSQ Histone-H3 COX-IV 1 1 * * 0.75 0.75 * SERCA2a relative amount TFAM relative amount 0.5 0.5 0.25 0.25 0 0 1 Vehicle 0.75 * * TFB2M relative amount H2O2 40 mmol/L 0.5 H2O2 40 mmol/L +Carvedilol 5 mmol/L Carvedilol 5 mmol/L 0.25 0 Vehicle Vehicle H2O2 40 mmol/L H2O2 40 mmol/L H2O2 40 mmol/L +Carvedilol 5 mmol/L H2O2 40 mmol/L +Carvedilol 5 mmol/L Carvedilol 5 mmol/L Carvedilol 5 mmol/L Whole-cell fraction p<0.05 vs. vehicle * Supplemental Figure1 Nuclear fraction Mitochondrial fraction

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