“ A Critical Role for AADR in Shaping the Future of Academic Dental and Craniofacial Research ”

1. AADR PRESENTATION TO ADEA ‘NEW DEANS’ “A Critical Role for AADR in Shaping the Future of Academic Dental and Craniofacial Research” Rena D’Souza, AADR President Christopher Fox, AADR Executive Director Nov 10th, 2012

2. Topics…… • How Dentistry Evolved - The Discoveries of Dentists that Shaped Health Care • Challenges and Opportunities for Dentistry - Can we Shape the Future? • Translational and Clinical Research - What ? Why ? How ? • Signature Initiatives from NIDCR/NIH • What is AADR’s Role?

3. The Beginnings….Barbers and Blacksmiths

4. Past 150 yrs • Horace Wells • William Morton • G.V. Black • Edward Angle • Truman Brophy • Willoughby Miller (1890)* -Bacterial basis for Oral Diseases -Disease Prevention (JADA: 140, 2009)

5. The Scientific Evolution of Dentistry • William J. Gies and the 1926 Carnegie Foundation Report on Dental Education • Dental Schools Incorporated as part of Health Sciences/Medical Centers and Universities • Development of Dental Scientific Journals and Publications in Medical and other Scientific Journals • The role of immigrant dental scientists from Europe • Opening of National Institute of Dental Research in 1948

6. The Challenges are Great Too !!! Those closest to the clinical challenges will generate the most pertinent and relevant questions. Hence a robust body of dental and craniofacial research findings should be emanating from our dental institutions How to translate discoveries about the DOC complex into better treatment and prevention of diseases and disorders while pushing the frontiers of basic science yet further ?

7. Our Needs Are Great!!!!

8. Challenges and Opportunities for Dentistry • Research is becoming more difficult to support • Grants are difficult to obtain • Higher % of NIDCR Funding outside dental schools • New schools with minimal infrastructure for research • Lack of formal training in clinical research methods • Need for better diagnostics, point-of-care therapeutics • Several studies available for translation • Increase in evidence-based instruction

9. Back to the Future…..

10. NIDCR, 2012

11. Personalized MedicinePredictive, Preventive, Precision Care • Personalized medicine in the sense of the ‘right treatment for the right patient at the right time”-has been practiced for millennia (Steele, F. Pers. Med. 2009.6,1-5) • Provides the ability to classify individuals into sub populations based on their susceptibility to a disease or response to a specific treatment

12. NIDCR 2012

13. NIDCR 2012

14. NCRR Supports the Continuum of Biomedical Research

15. Definition of Translational Research Translational research fosters the multidirectional integration of basic research, patient-oriented research, and population-based research, with the long-term aim of improving the health of the public (Rubio et al., 2010)

16. NIH definitions of clinical research Clinical Research. NIH defines human clinical research as (1) Patient-oriented research. Research conducted with human subjects (or on material of human origin) for which an investigator (or colleague) directly interacts with human subjects. Patient-oriented research includes: (a) mechanisms of human disease, (b) therapeutic interventions, (c) clinical trials, and (d) development of new technologies. (2) Epidemiologic and behavioral studies. (3) Outcomes research and health services research. NIDCR, 2012

17. Clinical Research • Traditional epidemiology studies • Mechanistic studies using patient samples • Other studies, such as cohort studies following subjects to determine outcomes of treatment(s). An example would be a study following individuals with diabetes and dental implants to determine if poor glucose control is associated with shorter implant survival. NIDCR, 2012

18. Educational and training opportunities • NIH CTSA program • Many translational training programs developed at CTSA institutions, many focused on training clinicians, but others focused on training basic scientists • CTSA institutions working to develop common training standards and best practices--core competencies under development • CTSA consortium creating a repository of programs (on-line and traditional) available at institutions around the country—National CTSA Educational Resource Program

20. WA ME MT ND VT OR MN NH WI ID SD NY MA MI WY RI PA IA NE NV OH MD IN DE IL UT CO WV KS VA CA MO KY NC TN OK AR AZ SC NM GA AL MS AK TX LA FL HI 2010-Building a National CTSA Consortium55 CTSA sites in 28 states and the District of Columbia NJ = IDeA-Eligible States PR = CTSA States = IDeA-Eligible State and CTSA Member

21. National Dental Practice- Based Research Network : NDPRN

22. NIDCR, 2012

23. NIDCR, 2012

24. NIDCR 2012

25. NIDCR, 2012

26. NIDCR, 2012

27. NIDCR, 2012

28. How can AADR Help? • Organize Information Transfer Sessions and Training Workshops at AADR Annual Sessions?? • Clinical Research Methodology ? • Research Mentoring Teams for Junior Faculty? • Practice-Based Research Network Forums ? • Meetings with Program Officers from Funding Agencies ? • Year-long AADR- Sponsored Activities ??? • Visits of President and Board Members to Schools ? • Activation of Local Chapters/Sections? • Dean Participation???

29. IADR/AADR Global HQ, Alexandria, VA Rena D’Souza, AADR President, rdsouza@bcd.tamhsc.edu Christopher Fox, AADR Executive Director, cfox@iadr.org