Scholarly Video Publishing to Increase Productivity and Standardization in Life Sciences

1. Scholarly Video Publishing to Increase Productivity and Standardization in Life Sciences Phill Jones, Ph.D. Editorial Director, Journal of Visualized Experiments

2. A brief history of scientific publishing 1665 – First scientific journal 1796 – Color Lithography 1993 – The pdf file • 2006 – The first Video Journal

3. What’s wrong with written protocols? • What’s so great about video? • The how and why of subscribing to JoVE?

4. The Problem: It’s hard to learn new techniques • Scientists have limited options • Materials and Methods sections • Not rigorous, cursory • Not taken seriously • Method Articles • Lack detail • Protocol Books • Slow to update • Very few protocols journals eg Nature Protocols • Do these solve the problem?

5. A picture tells a thousand words – Imagine what 20 frame per second can do Video Text article Position the metaphase spindle at 3 o’clock and hold it with the holding pipette. Apply piezo pulses to penetrate the zona pellucida. Touch the metaphase plate with the enucleation pipette. Aspirate the spindle and withdraw the pipette. What is this about???!!!

6. Structure of JoVE video-articles 1. Animated Abstract 2. Introduction of scientists 3. Experimental procedure 4. Discussion of results

7. The video is accompanied by a text protocol

8. JoVE: The worlds first scientific video JOURNAL • 3rd Party Validation • JoVE is a peer-reviewed Journal • - Indexed in PubMed and Medline • Prestigous Editorial Board • JoVE handles ALL production • Scripting • Videography • Editing • Voice-over • Onscreen text and graphics • Video Microscopy

9. Who watches JoVE? • A typical article receives 2,000 views in the first month and 10,000 in the first year • Runaway articles reach 40,0000 views • 80% of views are from IP addresses • that we know are inside an • acdemic institution Top 10 countries for users • USA • UK • Germany • India • China • Japan • France • Spain • Italy • Canada

10. Page loads Unique Visitors Returning Visitors Rapid growth in usage • 120,000 visitors per months • 250,000 downloads (2 pageloads per each visitor)

11. JoVE‘s Structure The main JoVE journal is complemented by several sections, specializing in… • Neuroscience • Immunology and Infection (I2) • Clinical and Translational Medicine* • Bioengineering* *Currently free upon registration

12. Why should you subscribe?1) We are Extremely useful You just can’t figure this stuff out on your own…..You need to be able to see it! Rich Condit, PhD Professor of Genetics and Microbiology, University of Florida Co-host of This week in Virology It is a great way of sharing the kinds of details that make all the difference but are very hard to put into a printed report. Helmut Hirsch, PhD, Distinguished Teaching Professor, University at Albany Super idea. Excellent movie. Best wishes with your novel publishing concept. Thomas D. Pollard, PhD Professor, Yale University I just viewed an excellent little article on your site, and I would like to include it in the reference materials for my course. Moses Goddard, MD Associate Professor of Surgery, Brown University

13. Why should you subscribe?2) We will save your institution money! • Implementing a new technique costs time and money • Some researchers even fly to a collaborators lab just to watch a technique first hand • Even within labs, when post-docs move on, they take knowledge with them • Post-docs need to ‘get up to speed’ and learn the lab techniques, often after the person who knew the technique has left! Doing the Maths A single Post-doc’s salary for 6 months while they learn a technique. (includes institution overhead) ≈ $40,000 How many post-docs does your institution hire a year? 50? ≈ $2,000,000

14. University of California in San Francisco Pre-subscription report Pre-subscription report Pre-subscription report Proving the point • We ask for IP ranges from Librarians to assess the number of people trying to access content on the site. • The numbers tend to be large • Obviously, once subscribed the numbers tend to go up even further.

15. Institutions subscribed - 2010 • >200 Institutions subscribed: • Harvard University, Oxford University, Massachusetts Institute of Technology – MIT, Brandeis University, Brown University, Cold Spring Harbor Laboratory – CSHL, Cornell University, Fred Hutchinson Cancer Research Center, George Mason University, Kent State University, Max-Planck-Institute for Medical Research (Germany), Mount Sinai School of Medicine – MSSM, National Institute of Health – NIH, National Taiwan University (Taiwan), Northeastern University of Illinois, Princeton University, Purdue University, Rockefeller University, Salk Institute, UC Davis, UC Irvine, UCLA, University of Verona (Italy), University of Hong Kong (Hong Kong), University of Iowa, University of Miami, University of New South Wales (Australia), University of Southern California – USC, University of Waterloo (Canada), University of Zurich (Switzerland), Vanderbilt University, Weizmann Institute of Science (Israel), Wellesley College, Yale University, Yonsei University (Korea),…

16. How to access us? • Currently we use IP authentication • No need for the user to log in • We ask the library for their institutional IP range • We’re currently in the final phase of becoming SAML2/ Shibboleth Compliant • Currently in talks with JISC but accepting individual subscriptions in the meantime

17. Your choice – what do you want for your users? Thank you for your attention

18. Who publishes with JoVE?

19. JoVE - Current Status • Published 40 montly issues, >650 video-articles • 50 video-articles per month are produced across the world • Areas covered: Neuroscience, Immunology, Developmental Biology, Cell Biology, Biochemistry, Bioengineering, Plant Biology, Psychology, Medicine and others • First-and-only video journal accepted for indexing in PubMed and Medline • - Most contributions from leading research universities in US and abroad: Harvard, MIT, Yale, NIH, Oxford, Cambridge, Max Planck, Weizmann Institute.... • Partnerships with traditional publishers: Science (AAAS), Current Protocols (Wiley), Springer Protocols (Springer) and Annual Reviews • Numerous articles in general and scientific press, TV and radio interviews (CNN, Nature, Science, WIRED, Voice of America, El Tiempo, ....)

20. JoVE has a professional video production team • JoVE handles ALL production • Scripting • Videography • Editing • Voice-over • Onscreen text and graphics • Video Microscopy

21. Who publishes what in JoVE? • - Group of Eric Lander (MIT, Broad Instittue) - genomics: • Hi-C: A Method to Study the Three-dimensional Architecture of Genomes • - Group of Rudolf Jaenisch (MIT) – stem cells: • Generating iPS Cells from MEFS through Forced Expression of Sox-2, Oct-4, c-Myc, and Klf4 • Group of Arturo Alvarez-Buylla (UCSF) – neural development: • The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow • Group of John Cooke (Stanford) – animal model of disease: • Murine Model of Hindlimb Ischemia • - Group of John Carlson (Yale) – behavior: • Proboscis Extension Response (PER) Assay in Drosophila

22. Testimonial I recently had the opportunity to publish in the Journal of Visualized Experiments (JoVE), the online video journal for biological sciences.  I came across JOVE when I was trying to understand the methodology of chromatin immunopreciptation assays.  The text is accompanied by video demonstrations which makes the methodology of the experiments much more clear. Thus, JOVE  is a very  unique and useful resource for researchers, graduate students, postdocs and undergraduates in science.  This novel visualization approach will improve reproducibility of experimental studies, and increase the efficiency of research and education in the biological sciences. Dr. John Cooke Professor of Medicine, Associate Director, Stanford Cardiovascular Institute.