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Amount of GDPs ( mg)

60. 3-DG. 3,4-DGE. 50. 5-HMF. Formaldehyde. 40. Amount of GDPs ( mg). 30. **. *. 20. 10. 0. Infused GDPs. GDPs found in urine. Figure 1. 500. Line fit: p = 0.0011 R = 0.87. 400. 300. CML increase (ng/ml). 200. 100. 0. 10. 20. 30. 40. 50. 60. 70. 80.

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Amount of GDPs ( mg)

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  1. 60 3-DG 3,4-DGE 50 5-HMF Formaldehyde 40 Amount of GDPs (mg) 30 ** * 20 10 0 Infused GDPs GDPs found in urine Figure 1.

  2. 500 Line fit: p = 0.0011 R= 0.87 400 300 CML increase (ng/ml) 200 100 0 10 20 30 40 50 60 70 80 Infused 3-DG (mg) Figure 2.

  3. 1200 ns ns ns * 1000 ** *** 800 ** IL-8 secretion (pg/ml) *** 600 400 200 0 Figure 3.

  4. Figure 4. ns ns * ** ** *** *** *** Relative Fluorescence Intensity 120 100 80 60 40 Infection 20 3-DG 5-HMF 3,4-DGE 0 Fluid nb. 2 Fluid nb. 3 Fluid nb. 3, sf Fluid nb. 2, sf Formaldehyde Positive control

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