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Supplementary Figures

Supplementary Figures. Normal. CRC. CRC+CPT11. CRC+5FU. S1. 100µm. 100µm. 100µm. 100µm. S2. A. NS. **. Gr-1 + CD11b + cells (%). CRC+ 5FU. CRC+ CPT11. Normal. CRC. B. **. Gr-1 + CD11b + cells (%). **. CRC+ CPT11. CRC+ 5FU. Normal. CRC. NS. NS. **. *.

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Supplementary Figures

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  1. Supplementary Figures Normal CRC CRC+CPT11 CRC+5FU S1 100µm 100µm 100µm 100µm

  2. S2 A NS ** Gr-1+ CD11b+ cells (%) CRC+ 5FU CRC+ CPT11 Normal CRC B ** Gr-1+ CD11b+ cells (%) ** CRC+ CPT11 CRC+ 5FU Normal CRC NS NS ** * CD247 (MFI) CD247 (MFI) CRC+ CPT11 CRC+ 5FU CRC+ CPT11 CRC+ 5FU Normal Normal CRC CRC

  3. S3 * CD4+ Foxp3+ cells (%) CRC+ CPT11 CRC+ 5FU Normal CRC

  4. S4 A B * *** No drug * 5FU * CPT11 ROS production (MFI) 5FU+CPT11 M-MDSCs G-MDSCs NS * C CD247 expression (MFI) D CRC +5FU +CPT11 CRC +CPT11 ** CRC+ 5FU+ CPT11 24.08% * Normal CRC CRC+ 5FU CRC+ CPT11 NS ** CRC +5FU MFI NO- production (MFI) NS 19.13% CRC M-MDSCs G-MDSCs NO- ROS 41.78% NS ** CD8+ cell proliferation (%) Normal 21.88% CRC+ 5FU+ CPT11 Normal Cell count CRC CRC+ 5FU CRC+ CPT11 7.11% Non-activated 65.06% CFSE

  5. S5 AOM AOM DSS DSS w1 w2 w3 w4 w5 w6 w7 w8 w9 w10 w11 Harvest Anti-Gr1 mAb injections

  6. S6 A B Cleaved caspase-3 (MFI) Cleaved caspase-3 (MFI) ** ** * CRC+ CPT11 CRC+ 5FU+ CPT11 CRC+ 5FU Normal CRC Cleaved caspase-3 (MFI) CRC+ CPT11 CRC+ 5FU+ CPT11 CRC+ 5FU Normal CRC M-MDSCs G-MDSCs No drug 5FU CPT11 5FU+CPT11

  7. S7 NS S100A8 A B ** S100A9 * ** * mRNA (RQ) mRNA (RQ) CRC CRC CRC+5FU CRC+5FU CRC+CPT11 CRC+CPT11 5FU µmol/L S100A9 C * NS * mRNA (RQ) mRNA (RQ) NS CPT11 µmol/L 5FU µmol/L mRNA (RQ) CPT11 µmol/L TNFα

  8. S8 A B C *** CD4+ Foxp3+ cells (%) *** Inflamed Inflamed - + + + + - + + + + Inflamed - + + + + - - + - + - - + - + 5FU 5FU - - + - + 5FU CPT11 CPT11 - - - + + - - - + + CPT11 - - - + + D E NS * NS Inflamed - + + + + ** - - + - + 5FU Gr-1+ CD11b+ cells (x106) * CPT11 - - - + + * Relative CD247 expression (%) * Relative CD247 expression (%) ** CD8+ cell proliferation (%) NS Inflamed - + + + + Relative CD247 expression (%) - - + - + 5FU CPT11 - - - + + Inflamed - + + + + 5FU - - + - + CPT11 - - - + +

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