BPH

1. BPH

2. Etiology • Most common benign tumor in men (Age related) • Multifactorial and endocrine controlled • BPH is under endocrine control • (+) correlation between levels of free testosterone and estrogen and the volume of BPH • No studies to date has demonstrated eleveated estrogen receptor levels in human BPH

4. Pathology • BPH develops in transition zone. • Increase in cell number – Microscopic examination reveals a nodular growth pattern that is composed of varying amounts of stroma and epithelium. • Stroma is composed of collagen and smooth muscle • As BPH nodules in the transition zone enlarge, they compress the outer zones of the prostate, resulting in formation of so called surgical capsule

5. This boundary seperates the transition zone from the peripheral zone and serves as a cleaveage plane for open enucleation of prostate during open simple prostatectomies

6. Pathophysiology • As prostatic enlargement occurs, mechanical obstruction may result from intrusion into the lumen. The surrounding capsule prevents it from radially expanding leading into urethral compression. • The bladder wall becomes thickened, trabeculated, and irritable when it is forced to hypertrophy and increase its own contractile force

7. This increased sensitivity (detrusor instability), even with small volumes of urine in the bladder, is believed to contribute to urinary frequency and LUTS. • The bladder may gradually weaken and lose the ability to empty completely, leading to increased residual urine volume and, possibly, acute or chronic urinary retention.

8. Testosterone (T) diffuses into the prostate epithelial and stromal cell. T can interact directly with the androgen (steroid) receptors bound to the promoter region of androgen-regulated genes. In the stromal cell, a majority of T is converted into dihydrotestosterone (DHT)—a much more potent androgen, which can act in an autocrine manner in the stromal cell or in a paracrine manner by diffusing into epithelial cells in close proximity. DHT produced peripherally, primarily in the skin and liver, can diffuse into the prostate from the circulation and act in a true endocrine manner. In some cases, the basal cell in the prostate may serve as a DHT production site, similar to the stromal cell.1

10. Laboratory Work up

11. Imaging Studies

12. Cystoscopy The procedure involves inserting a tube into the urethra through the opening at the end of the penis. It allows the doctor to visually examine the complete length of the urethra and the bladder for polyps, strictures (narrowing), abnormal growths, and other problems.

13. Additional Tests

14. Differential Diagnosis Bladder Cancer Bladder Stones Bladder Trauma Urethral Strictures Chronic Pelvic Pain Urinary Tract Infection,Males Interstitial Cystitis NeurogenicBladder Prostatitis, Bacteria

15. 5 alpha reductase inhibitors like Finasteride and Dutaseride are another treatment option. • They inhibit 5alpha reductase which inhibits production of DHT which is responsible for enlarging the prostate • Side effects include decreased libido and ejaculatory or erectile dysfunction

16. Treatment • The two main medications for management of BPH are alpha blockers and 5α-reductase inhibitors. • Alpha blockers (technically α1-adrenergic receptor antagonists). Alpha blockers used for BPH include doxazosin,terazosinalfuzosintamsulosin and silodosin. • Alpha blockers relax smooth muscle in the prostate and the bladder neck, thus decreasing the blockage of urine flow. Common side effects of alpha blockers include orthostatic hypotension, ejaculation changes, nasal congestion, and asthenia.

17. Antimuscarinicsshuch as Tolterodine can also be used especially with combination with alpha blockers. • They act by decreasing acetylcholine effects on the smooth muscle wall of the bladder. This results in helping and controlling the symptoms of an overactive bladder