Supplemental Figure 2

Molecularly defined NKCL Median expression -ENKTL NKCL CT(α)-PTCL Median expression CT(α)-PTCL NKCL -ENKTL -SIGLEP3 -ITAGD -KIR2DL4 -TCR- -KLRC3 -KLRC4 -IL34 -IL18BP -CSTW -CXCL3 -PTCL (NHS) CT(α)-PTCL -PTCL (NHS) CT(α)-PTCL -TCR- -LAT2 -IL2RB -KLRC3 -CD244 -NCR1 -NCAM1 -SH2D1B -SH3BP1 -FCRLB -KIR2DL4 -TRD -CTSW -CTSD -IL10RA -KLRK1 -KLRC2 -KLRC3 -KLRC4 -IKZF2 -PRF1 -GZMA -TGFBRAP1 -KIR2DS5 -IL23A -NKG7 -FCRLB -KLRC2 -PTGER2 -IL23A -SH2DIB(EAT2) -FCRLB -NCAM1(CD56) -NCR1(NK-p46) -CD244 (2B4)) -SH2D3 • CCR7 • ETV1 • NRAS • IK2F1 • RUNX2 • IZKF1 • IL11 Representative transcripts Representative transcripts • CD3D • CD3G • CD4 • CD5 • TCR- • CD6 • CD27 • CD28 • CD226 • CD25 • CD5 -CD5 -CD28 -CD82 -CD27 -CD30 -CADM1 (TSCL1) -CCR7 -CCR9 -CCR10 -MALT1 -IKZF1 -TCR- -MAL -PKIA -TCF4 -IL27RA (NKCL refers only to lymphomas of NK-cell lineage including ENKTL and, ANKL and -T represent two cases of ENKTL with  T-cell lineage) TCR- (median) TCR-α (median) SupplementalFigure 2 (B) (A) Molecularly defined

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