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Sampling points (hour post-dose)

Kasteleijn-Nolst Trenité. E-Figure 1. (B). (A). Dizziness. 60. 60. Somnolence. Dizziness. 100. 100. 50. 50. 40. 40. 10. 10. GBP. Plasma concentration (µg/mL). 30. Photosensitivity window (Hz). Photosensitivity window (Hz). Plasma concentration (µg/mL). 30. 1. 1. 20. 20.

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Sampling points (hour post-dose)

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  1. Kasteleijn-Nolst Trenité E-Figure 1 (B) (A) Dizziness 60 60 Somnolence Dizziness 100 100 50 50 40 40 10 10 GBP Plasma concentration (µg/mL) 30 Photosensitivity window (Hz) Photosensitivity window (Hz) Plasma concentration (µg/mL) 30 1 1 20 20 10 10 0.1 0.1 BRV BRV 0 0.05 0 0.05 PD 0.5 1 2 4 6 8 PD 0.5 1 2 4 6 8 24 28 PD 0.5 1 2 4 6 8 PD 0.5 1 2 4 6 8 24 28 Placebo Brivaracetam 20 mg Placebo Brivaracetam 10 mg Sampling points (hour post-dose) Sampling points (hour post-dose) (D) (C) 60 60 Dizziness 100 100 50 50 40 40 10 10 LTG Plasma concentration (µg/mL) Plasma concentration (µg/mL) Photosensitivity window (Hz) Photosensitivity window (Hz) 30 30 1 1 20 20 10 10 0.1 0.1 BRV BRV 0 0.05 0 0.05 PD 0.5 1 2 4 6 8 PD 0.5 1 2 4 6 8 24 28 32 48 72 PD 0.5 1 2 4 6 8 PD 0.5 1 2 4 6 8 24 28 32 48 72 Placebo Brivaracetam 80 mg Placebo Brivaracetam 40 mg Sampling points (hour post-dose) Sampling points (hour post-dose)

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