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Respiratory System and Breathing Mechanics

This text provides an overview of the respiratory system, including the organs involved, the mechanics of breathing, and respiratory disorders such as COPD, lung cancer, asthma, bronchitis, and tuberculosis.

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Respiratory System and Breathing Mechanics

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  1. Warm-Up • Name the organs forming the respiratory passageway from the nasal cavity to the alveoli of the lungs. • Explain how the respiratory muscles cause volume changes that lead to breathing. • Sally has a vital lung capacity of 3900 ml. Her tidal volume is 400 ml. Her expiratory reserve volume is 1000 ml. What is her inspiratory reserve volume?

  2. Respiratory System

  3. Respiratory System Function: supply O2 to the blood and remove CO2

  4. Anatomy • Nose/mouth: filtered, warmed, humidified • Mucus traps bacteria & foreign debris • Cilia sweep mucus toward throat  digested by stomach • Pharynx: throat (passage for food/air) • Tonsils: clusters of lymphatic tissue • Larynx: contains vocal cords • Epiglottis: covers larynx when liquids/food swallowed • Trachea: windpipe; lined with cartilage (C-shaped) • Bronchi: branches to lungs • Bronchioles: smaller branches • Lungs  Alveoli: air sacs for gas exchange

  5. pharynx

  6. Vocal cords

  7. Lungs

  8. Alveoli

  9. Mechanics of breathing • Inspiration: air flowing into lungs • Expiration: air leaving lungs Muscles: • Diaphragm: dome-shaped muscle separating thoracic and abdominal cavities • External intercostals: pulls ribs to elevate rib cage  inspiratory muscles • Internal intercostals: depresses rib cage

  10. Diaphragm contracts & flattens • External intercostals lifts rib cage • Lungs stretched to larger size • Air pressure inside lungs decrease • Air sucked into lungs • Inspiratory muscles relax • Rib cage descends, lungs recoil • Gases forced out Inspiration Expiration

  11. Inspiration vs. expiration

  12. Respiratory capacity • Factors that affect capacity: size, age, sex, physical condition

  13. Vital Capacity (VC): total exchangeable air VC = TV + IRV + ERV • Tidal Volume (TV): amount of air in/out during normal breath (~500ml) • Inspiratory Reserve Volume (IRV): forced in air over tidal volume (~3100) • Expiratory Reserve Volume (ERV): air forcibly exhaled (~1200) • Residual Volume (RV): air still left in lungs (~1200) • allows gas exchange to continue between breaths

  14. spirometer • Used to measure respiratory capacities

  15. Gas transport in blood • Oxygen: attaches to hemoglobin molecules inside RBC’s • Hemoglobin: respiratory pigment, contains 4 heme groups with iron (Fe)

  16. Gas transport in blood Carbon dioxide: • Transported as bicarbonate ions (70%) • Bound to hemoglobin (23%) • Dissolved in plasma (7%)

  17. Control of Respiration • Control center = medulla oblongata • Responds to pH changes in blood • High CO2 carbonic acid forms  lowers pH • O2 sensors in the aorta and carotid arteries

  18. Respiratory Disorders

  19. chronic obstructive pulmonary disease (COPD) • Group of lung diseases  blocks airflow and makes breathing difficult • Emphysema (lose elasticity of lung tissue) & chronic bronchitis(excess mucus) • Features: • History of smoking • Labored breathing (wheezing, shortness of breath) • Coughing & frequent pulmonary infections • Hypoxic (inadequate O2 delivery – bluish skin)

  20. emphysema

  21. Lung cancer • Uncontrolled growth of abnormal cells in lungs • #1 cause of cancer deaths • Leading cause = SMOKING • Low survival rate (avg. 9 mths after diagnosis) • Contributes to atherosclerosis, heart disease • Treatment: remove diseased lobes, radiation, chemotherapy

  22. Respiratory Disorders • Asthma: inflamed, hypersensitive bronchial passages that respond to irritants • Bronchitis: bronchi swollen and clogged • Pneumonia: inflammation of lung caused by infection • Tuberculosis (TB): infectious disease caused by M. tuberculosis bacterium

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