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Antiphospholipid Syndrome

Antiphospholipid Syndrome. Dror Mevorach, MD November , 2013. Antiphospholipid Syndrome. APLS is a disorder of recurrent arterial or venous thromboses, pregnant losses, and/or thrombocytopenia associated with persistently positive results of anticardiolipin or lupus anticoagulant tests.

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Antiphospholipid Syndrome

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  1. Antiphospholipid Syndrome Dror Mevorach, MD November , 2013

  2. Antiphospholipid Syndrome • APLS is a disorder of recurrent arterial or venous thromboses, pregnant losses, and/or thrombocytopenia associated with persistently positive results of anticardiolipin or lupus anticoagulant tests

  3. Antiphospholipid Syndrome History I • A hemorrhagic disorder caused by circulating anticoagulant in a patient with SLE. Conley & Hartmann, JCI, 1952 • Thrombosis in SLE “despite” circulating anticoagulants. Bowie et al., JCI, 1963 • A peripheral vascular syndrome overlapping with SLE. Johansson et al., Dermatologia, 1977 • Intra-uterine death and circulating anticoagulant. Nilsson et al., Acta Med Sand, 1975

  4. Antiphospholipid Syndrome History II • Lupus anticoagulants binds negatively charged phopholipids. Thiagarajan et al., JCI, 1980 • Anticardiolipin antibodies: detection with RIA and association with thrombosis in SLE. Harris et al, Lancet, 1983

  5. Antiphospholipid Syndrome Laboratory False positive for syphilis: Common antigen: cardiolipin-cholesterol-phophatidylcholine • Agglutination: RPR (rapid plasma reagin) • Flocculation: VDRL (Veneral disease research laboratories) • Complement fixation: Wasserman No false positive syphilis: • FTA-ABS (fluorescent treponemal antibody absorbed assay)

  6. Anticardiolipin • IgG • IgM • IgA • b2GPI • Low titer: 10 GPL/MPL/APL • Medium titer: 20/30-60 • High titer: >60 • Correlation with thrombosis: High>Medium>>low IgG>>IgM>IgA

  7. Lupus anticoagulant

  8. Anticardiolipin False+ VDRL Lupus anticoagulant Anti-b2GPI The different anti-phospholipids autoantibodies share antigen epitopes but are also targeted against different epitopes

  9. Antiphospholipid Syndrome Clinical criteria: • One or more clinical episodes of arterial, venous or small vessel thrombosis, in any tissue or organ. Thrombosis must be confirmed by imaging or doppler studies or histopathology, with the exception of superficial venous thrombosis. For histologic confirmation, thrombosis should be present without significant evidence of inflammation in the vessel wall. Arthritis @ Rheum 1999;42 (7):1309-1311

  10. Antiphospholipid Syndrome • Clinical criteria: • 2. Pregnancy morbidity • -One or more premature births of a morphologically normal neonate at or before the 34th week of gestation because of severe preeclampsia or eclampsia, or severe placental insufficiency OR • -Three or more unexplained consecutive spontaneous abortions before the 10th week of gestation, with maternal anatomic or hormonal abnormalities and paternal and maternal chromosomal cause excluded • Arthritis @ Rheum 1999;42 (7):1309-1311

  11. Antiphospholipid Syndrome Laboratory criteria (I): 1. Anticardiolipin antibody of IgG and/or IgM isotype in blood, present in medium or high titer, on 2 or more occasions, at least 6 weeks apart, measured by a standardized ELISA for beta-2-GPI-dependent anticardiolipin antibodies.

  12. Antiphospholipid Syndrome • Laboratory criteria (II): • 2. Lupus anticoagulant present in plasma, on 2 or more occasions at least 6 weeks apart, detected according to the guidelines of the International Society on Thrombosis and Homeostasis in the following steps: • Prolonged phospholipid-dependent coagulation demonstrated on a screening test, e.g. activated PTT, KCT, dilute RVVT, dilute prothrombin time, Textarin time.

  13. Antiphospholipid Syndrome • Laboratory criteria (III): • 3. Failure to correct the prolonged coagulation time on the screening test by mixing with normal platelet-poor plasma. • Shortening or correction of the prolonged coagulation time on the screening test by the addition of excess phospholipid. • Exclusion of other coagulopathies.

  14. Antiphospholipid Syndrome Definite antiphospholipid syndrome is considered to be present if at least 1 of the clinical (thrombosis or pregnant morbidity) and 1 of the laboratory(anticardiolipin or lupus anticoagulant) criteria are met

  15. Arterial thrombosis: Aorta, eye, hepatic, splenic, brain, etc. Venous thrombosis: DVT, portal Cardiac: Non-infectious endocarditis, CAD Cutaneous: Splinter Hemorrhages, levido reticularis, skin infarcts Neurologic: TIA, CVA, seizures, dementia, TM Obstetrical: Pregnancy loss, IUGR, HELLP syndrome, pre-ecampsia Hematologic: Thrombocytopenia, hemolytic anemia, leukopenia Antiphospholipid Syndrome:Clinical spectrum

  16. Arterial thrombosis: Aorta, eye, hepatic, splenic, brain, etc. Venous thrombosis: DVT, portal Cardiac: Non-infectious endocarditis, CAD Cutaneous: Splinter Hemorrhages, levido reticularis, skin infarcts Neurologic: TIA, CVA, seizures, dementia, TM Obstetrical: Pregnancy loss, IUGR, HELLP syndrome, pre-ecampsia Hematologic: Thrombocytopenia, hemolytic anemia, leukopenia Antiphospholipid Syndrome:Clinical spectrum

  17. Arterial thrombosis: Aorta, eye, hepatic, splenic, brain, etc. Venous thrombosis: DVT, portal Cardiac: Non-infectious endocarditis, CAD Cutaneous: Splinter Hemorrhages, levido reticularis, skin infarcts Neurologic: TIA, CVA, seizures, dementia, TM Obstetrical: Pregnancy loss, IUGR, HELLP syndrome, pre-ecampsia Hematologic: Thrombocytopenia, hemolytic anemia, leukopenia Antiphospholipid Syndrome:Clinical spectrum

  18. Arterial thrombosis: Aorta, eye, hepatic, splenic, brain, etc. Venous thrombosis: DVT, portal Cardiac: Non-infectious endocarditis, CAD Cutaneous: Splinter Hemorrhages, levido reticularis, skin infarcts Neurologic: TIA, CVA, seizures, dementia, TM Obstetrical: Pregnancy loss, IUGR, HELLP syndrome, pre-ecampsia Hematologic: Thrombocytopenia, hemolytic anemia, leukopenia Antiphospholipid Syndrome:Clinical spectrum

  19. Arterial thrombosis: Aorta, eye, hepatic, splenic, brain, etc. Venous thrombosis: DVT, portal Cardiac: Non-infectious endocarditis, CAD Cutaneous: Splinter Hemorrhages, levido reticularis, skin infarcts Neurologic: TIA, CVA, seizures, dementia, TM Obstetrical: Pregnancy loss, IUGR, HELLP syndrome, pre-ecampsia Hematologic: Thrombocytopenia, hemolytic anemia, leukopenia Antiphospholipid Syndrome:Clinical spectrum

  20. Antiphospholipid Syndrome Treatment: • Anticoagulation • Corticosteroids ??? Prevention? Aspirin or low dose LMW heparin for pregnancy loss Full anticoagulation for recurrent thrombotic event Hydroxychloriquine (in SLE) ?

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