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Some thoughts!!

Explore the sequestration of metabolites in tissues and plasma pool kinetics, focusing on the impact of dietary patterns on biomarkers using stable isotopes and genotypic analysis.

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Some thoughts!!

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  1. Some thoughts!!

  2. Frequently consumed foods

  3. Foods consumed occasionally

  4. Infrequently consumed foods – but nutritionally important

  5. Sequestration of metabolites in bone, fat and other tissues Plasma pool

  6. Kinetics of metabolite appearance and disappearance in plasma • Kinetics are metabolite specific • Influenced by host genotype • Does concentration fall to zero? • Impact of repeated exposure?

  7. Biomarkers of food intake • follow-up feeding studies (shorter and longer) • Impact of gut microflora • Use of an external marker • Use of stable isotopes to indentify food specific biomarker • Panels or single biomarkers • Quantification (how much orange juice) • Dietary patterns: panel of markers (PHN) • Biofluids: urine and blood; most practical

  8. metabotypes: • How to distinguish? • Numbers necessary to perform. • How many metabotypes? • Genotype: importance: need genotype metabolomic studies to put

  9. Run-in diet: - necessary, improves the repeatability of the study - Length will depend on study in question

  10. Concluding Remarks - Exactly what you do will depend on the study and questions to be answered

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