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Circulatory Systems Group

Circulatory Systems Group. Afternoon Session. Knowledge Gaps and Research Opportunities. What we know about the clinical epidemiology of stroke Large vs small vessel disease Differences in risk factors, their interactions Positive protective factors Consider vascular system as an “organ”

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Circulatory Systems Group

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  1. Circulatory Systems Group Afternoon Session

  2. Knowledge Gaps and Research Opportunities • What we know about the clinical epidemiology of stroke • Large vs small vessel disease • Differences in risk factors, their interactions • Positive protective factors • Consider vascular system as an “organ” • Understand the role of HIF, NO, and EPO as protective factors in the brain

  3. Knowledge Gaps and Research Opportunities (2) • Genetic methods to look at stroke-related genes and polymorphisms in large vs small vessel strokes • Animal models for stroke, particularly small vessel disease. • Interactions of race/ethnicity and gender for anemia and vascular disease • Risk and protective factors • Across aging transitions (e.g., hormonal changes)

  4. Knowledge Gaps and Research Opportunities (3) • Mechanisms through which HIF effects cognition, affect, and mobility • Effects of the Renin Angiotensin System (RAS) on cognition, affect and muscle function • Attention to vascular function instead of morphology • Differential effects of risk factors and treatment on large vessel vs microvascular disease • Effects of stress on hpertension and vascular disease

  5. Knowledge Gaps and Research Opportunities (4) • How to identify/define specific symptoms related to vascular causes of cognitive, affective, and mobility dysfunctions compared to other causes. • Improved methods for imaging brain vasculature, function and control – especially for small vessels. • Tools for measurement of related functions that are compatible with imaging technologies. • Continuous monitoring of multiple aspects of cardiovascular and cerebrovascular function.Attention to vascular function instead of morphology • Intervention studies – incorporate intermediate and distal outcomes measures for TMF. • Role of lipids in cardiovascular function

  6. Research Priorities: Unravel the Role of the Cardiovascular System in TMK • Understand specific phenotypic characteristics aTMFssociated with different manifestations of cerebrovascular disease • Large vs small vessels • Develop tool for continuous and simultaneous monitoring of a variety of physiologic processes that contribute to TMF • How to leverage protective mechanisms such as HIF, NO, or EPO to modulate ischemic damage in organs controlling THF • Animal models to study small vessel disease (e.g., NOTCH3)

  7. Research Priorities • Examine mechanisms through which cardiac diseases and inteventions influence cebrovascular and muscular function • Valvular disease • Heart failure • Atrial Fibrillation • Post-pump syndrome

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