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Acclimatization - High Altitude

Acclimatization - High Altitude. Fig. 37-5 Ganong . Acclimatization - Mechanisms. Peripheral Chemoreceptors detect decreased [O 2 ]. Increased cardiac output Increased ventilation short term:  65% hyperventilation   [CO 2 ]  central chemoreceptors inhibit further ventilation

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Acclimatization - High Altitude

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  1. Acclimatization - High Altitude Fig. 37-5 Ganong

  2. Acclimatization - Mechanisms • Peripheral Chemoreceptors detect decreased [O2]. • Increased cardiac output • Increased ventilation • short term:  65% • hyperventilation   [CO2]  central chemoreceptors inhibit further ventilation • long term:  300-700% • adaptation of central chemoreceptors to higher-than-normal blood pH • cf. emphysema (“pink puffers”)

  3. Acclimatization - Mechanisms • Hemoglobin •  hematocrit • altered affinity for O2 • Lungs •  size •  perfusion • Tissues •  angiogenesis

  4. Deep Sea Situations • 33 = 1 atm • N2 • nitrogen narcosis • “the bends” • O2 • excessive oxidation • CO2 • acidosis

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