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Design of a Simulation Toolbox for Gastrointestinal Electrical Activity

Design of a Simulation Toolbox for Gastrointestinal Electrical Activity. BME 273: Senior Design Projects John F Gouda Advisor: Dr. Alan Bradshaw, Ph.D. Motivation of Project. The living state physics group have state of the art equipment to measure the magnetic field of the intestine.

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Design of a Simulation Toolbox for Gastrointestinal Electrical Activity

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  1. Design of a Simulation Toolbox for Gastrointestinal Electrical Activity • BME 273: Senior Design Projects • John F Gouda • Advisor: Dr. Alan Bradshaw, Ph.D.

  2. Motivation of Project • The living state physics group have state of the art equipment to measure the magnetic field of the intestine. • The magnetic field can be used to estimate the electric field: trans-membrane potential and slow currents. • Thus, the need arose for a simulation environment that allows the user to create a dynamics model of GI electrical activity.

  3. Solution-Neutral Problem Statement • How can we make a simulation toolbox that can be used to simulate gastrointestinal (GI) electrical activity?

  4. Design SpecificationsUser Demands • The simulation toolbox should: • 1. Give the user an intuitive grasp of GI electrical activity • 2. Rely on an accurate model of GI electrical activity • 3. Rely on an intuitive model of GI electrical activity • 4. Relate model simulations with experimental data

  5. Project SpecificationsUser Wishes • If possible, the simulation toolbox should: • 1. Have a user-friendly interface • 2. Provide the user with “on the spot” calculations and metrics that represent the response of the model to the parameters supplied to the toolbox. Provide the user with a measure of goodness of fit with experimental data.

  6. Wishes Continued • 3. Provide the user with “on the spot” graphics that represent the response of the model to the parameters supplied to the toolbox • 4. Provide the user with analysis modules that can analyze the complexity of GI activity and provide intuition into the physiologic function of GI tract.

  7. Background • 1960 Nelson and Becker suggest that a chain of relaxation oscillators (RO) could simulate GI electrical activity. • 1971 Sarna et al. Used a modified version of the Van der Pol oscillator to simulate GI electrical activity • The name “relaxation oscillators” comes into place because the “stress” accumulated during the slow buildup is “relaxed” during the sudden discharge.

  8. Core conductor models • The parameters of relaxation oscillators can not be directly related to physiologic parameters (i.e. ion channels and cell coupling). • Models based on ionic mechanisms of membrane activity and on symmetric electrical coupling of cells are called core conduction models.

  9. Our model • We proposed a simple model that attempts to combine the mathematical utility and simplicity of relaxation oscillators and the physiologic intuition of core-conductor models. • Two muscle layers: longitudinal muscle (LM) and interstitial cells of Cajal (ICC) • The model consists of 4 (2 for each muscle layer) nonlinear coupled partial differential equations in time and space.

  10. Current status of project • 1. A preliminary mathematical model was formulated. • 2. The modeling environment will be the differential equation editor interfacing with Simulink interfacing with Matlab. • 3. An initial prototype is currently being developed.

  11. Budget • Need a Simulink manual?

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