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Explore the bioinformatics advancements at CIPF in Valencia: genomics, regenerative medicine, and cell therapy. Discover GEPAS for DNA array data analysis and upcoming training courses in microarray data analysis. Join the movement shaping the future of CAMDA.
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CAMDA 07CIPF, Valencia, Spain East coast of Spain, mediterranean warm wheather.
Modern city with near 1M inhabitants. • Agroalimentary industry (oranges, rice), R&D and biomedicine • Rich gastronomy (paella) • Old traditions: fire festival (fallas) Valencia
The city of the arts and the science The CIPF is located in Valencia downtown, in a wonderful environment surrounded by museums, exhibition centers, an opera theater and the biggest aquarium in Europe
Scientific programs of the CIPF Genomics and pharmacoproteomics Regenerative medicine • Cell therapy for: • Diabetes • Parkinson, Ictus • Cardiovascular • Spinal cord lesions • Skin regeneration • Osteoarthritis y reumathoid arthritis
The bioinformatics department at Centro de Investigación Príncipe Felipe (Valencia, Spain)... Joaquín Dopazo Eva Alloza Leonardo Arbiza Fátima Al-Shahrour Jordi Burguet Lucía Conde Hernán Dopazo Toni Gabaldon Jaime Huerta Ignacio Medina Pablo Minguez David Montaner Joaquín Tárraga Juan Manuel Vaquerizas ...and the INB, Instituto Nacional de Bioinformática (Functional Genomics Node)
Algorithms are used if they are available in programs.GEPAS, a package for DNA array data analysis Free web-based platform. Computer independent. Heavy calculations are made on the server side. New versions are immediately available. Covers 70-80% of the normal calculation necessities in microarray data analysis. The GEPAS team (three people full time plus up to 15 people involved) External Avdvisors’ committee (J. Quackenbush, S. Dudoit, Y. Moreau) More than 150.000 experiments analysed in 2005, more than 500 per day User’s profile: USA, UK, Germany, France Japan, ... http://www.gepas.org ; http://gepas.bioinfo.cipf.es
Two-colour arrays http://www.gepas.org Blocks of genes Multi classes T-Rex DNMAD Survival Two classes Correlation GSEA Preprocessor Random forest FatiScan Tnasas DLDA KNN SVM Expresso Babelomics Affymetrix arrays FatiGO+ ISACGH Marmite CAAT TMT FatiGO Raw data SOM Hierarchical Two sets of genes K-means SOTA Normalization Clustering GEPAS Differential expresion Arrays-CGH Class Prediction Functional Annotation Herrero et al., 2003, 2004; Vaquerizas et al., 2005 NAR; Montaner et al., 2006 NAR; Al-Shahrour et al., 2005, 2006 NAR; 2005 Bioinformatics RIDGE analysis
More than 150,000 experiments analysed during the last year. More than 500 experiments per day. Usage statistics 24h usage map as of June 8, 2006
Courses: http://bioinfo.cipf.es/docus/courses/courses.html • 22 - 24 March 2006 II - Course on Microarray Data Analysis. Centro de Investigación Príncipe Felipe - Valencia • 19 -21 April 2006 EMBO Practical Course on Comparative Genomics and SNP Analysis using the Ensembl Genome Browser. Centro de Investigación Príncipe Felipe - Valencia • 15 - 19 Mayo 2006 Evolución Molecular, Filogenia y Filogenómica. Centro de Investigación Príncipe Felipe - Valencia • 22nd-24th May 2006 Course on Microarray Data Analysis. Graduate School of Biological, Medical and Veterinary Sciences. University of Cambridge. UK • June 2006 Course on Microarray Data Analysis. Gulbenkian Inst. Lisbon (Portugal) • September 2006 Course on Microarray Data Analysis. Cape Town (SA) • November 2006 Course on Microarray Data Analysis. Las Palmas de Gran Canaria • November 2006 Course on Microarray Data Analysis. Graduate School of Biological, Medical and Veterinary Sciences. University of Cambridge. UK Increasing demand
The INB, a “Virtual” Institute Training F.Sanz - UPF With F. Martin ISCIII, F. Moran UCM Computational Node 2 X.Messeguer –UPC /Barcelona Supercomputer Center Bioinformatics and Genomics R.Guigo – IMIM/CRG Central Node Bioinformatics and Proteomics A.Valencia – CNB/CSIC Protein Structure M-Orozco – Univ. Barcelona Parc Cientific Barcelona Computational Node 1 J.M. Carazo – PCM Functional Genomics J.Dopazo – CIPF Integrated Bioinformatics O.Trelles – Univ. Malaga
INB Status Technological platform of Genoma España INB is organized as a Network Managed as a standard multi- institution project Total endowment to the project for 3 years: 4.443.358 €
There is a growing interest in Spain in microarray-based technologies Demand in training activities Genoma España is promoting the use of microarrays, by means of subsides. Bioinformatics and CeGen (large-scale genotyping) are funded as virtual institutes
Future of CAMDA Itinerant international conference. Who is next? Dataset-driven or topic-driven? Maybe both... Proceedings? Selection of n* best papers for a section in an issue of a journal? Training: demos? Tutorials? Sponsors: companies, local/national government, etc. * n=10?